The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

In the last decade, we witnessed discoveries that established Zn2+ as a second major
signalling metal ion in the transmission of information within cells and in communication …

The biological activity of selenium is dependent upon its speciation. We aim to integrate
selenium speciation and metabolism into a discussion of the mechanisms by which …

Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …

Biology capitalizes on the specific chemistries of certain transition metal ions. In fact, life
depends on transition metal ions as essential trace elements. Biological redox processes …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Sulfur and selenium occur in proteins as constituents of the amino acids cysteine,
methionine, selenocysteine, and selenomethionine. Recent research underscores that these …

In biological systems, the amino acid cysteine combines catalytic activity with an extensive
redox chemistry and unique metal binding properties. The interdependency of these three …

Numerous studies in animal models and more recent studies in humans have demonstrated
cancer chemopreventive effects with Se. There is extensive evidence that monomethylated …

It has become increasingly evident that chronic inflammation underpins the development of
many chronic diseases including cancer, cardiovascular disease and type 2 diabetes …