Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells
(HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to …

Hematopoietic stem and progenitor cells (HSPCs) are considered as a heterogeneous
population, but precisely when, where and how HSPC heterogeneity arises remain largely …

It has been over three decades since Drs. Herzenberg and Herzenberg proposed the
layered immune system hypothesis, suggesting that different types of stem cells with distinct …

Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium (HE) in the aorta-
gonads-and mesonephros (AGM) region and reside within Intra-aortic hematopoietic …

Besides its canonical role in protecting the host from pathogens, the immune system plays
an arguably equally important role in maintaining tissue homeostasis. Within barrier tissues …

Traditional models of lymphopoiesis present B and T cell development as a linear process
that initiates in the fetus and continues after birth in the bone marrow and thymus …

As a population of homogeneous cells with both self-renewal and differentiation potential,
stem cell pools are highly compartmentalized and contain distinct subsets that exhibit stable …

Hematopoietic stem cells (HSCs) produce all blood cell lineages and maintain life‐long
hematopoiesis. However, the self‐renewal ability and differentiation capacity of HSCs …