Modulating the immune system as a therapeutic target for myelodysplastic syndromes and acute myeloid leukemia
CM Putnam, L Kondeti, MBA Kesler… - Biochemistry and Cell …, 2023 - cdnsciencepub.com
Modulating the immune system to treat diseases, including myeloid malignancies, has
resulted in the development of a multitude of novel therapeutics in recent years …
resulted in the development of a multitude of novel therapeutics in recent years …
Y‐box binding protein 1 in small extracellular vesicles reduces mesenchymal stem cell differentiation to osteoblasts—implications for acute myeloid leukaemia
VK Chetty, J Ghanam, K Lichá… - Journal of …, 2024 - Wiley Online Library
Small extracellular vesicles (sEVs) released by acute myeloid leukaemia (AML) cells have
been reported to influence the trilineage differentiation of bone marrow‐derived …
been reported to influence the trilineage differentiation of bone marrow‐derived …
Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression
M Mendes, AC Monteiro, E Neto, CC Barrias… - International Journal of …, 2024 - mdpi.com
Acute myeloid leukaemia (AML) management remains a significant challenge in oncology
due to its low survival rates and high post-treatment relapse rates, mainly attributed to …
due to its low survival rates and high post-treatment relapse rates, mainly attributed to …
Elevated plasma levels of IL-6 and MCP-1 selectively identify CML patients who better sustain molecular remission after TKI withdrawal
C Pavlovsky, B Vasconcelos Cordoba… - Journal of Hematology & …, 2023 - Springer
Abstract Treatment-free remission (TFR) in chronic myeloid leukemia (CML) is safe under
adequate molecular monitoring, but questions remain regarding which factors may be …
adequate molecular monitoring, but questions remain regarding which factors may be …
Higher PD-1/Tim-3 expression on IFN-γ+ T cells is associated with poor prognosis in patients with acute myeloid leukemia
S Huang, Y Zhao, W Lai, J Tan, X Zheng… - Cancer Biology & …, 2023 - Taylor & Francis
With the success of immune checkpoint inhibitors (ICI), such as anti-programmed death-1
(PD-1) antibody for solid tumors and lymphoma immunotherapy, a number of clinical trials …
(PD-1) antibody for solid tumors and lymphoma immunotherapy, a number of clinical trials …
Expression profiling of extramedullary acute myeloid leukemia suggests involvement of epithelial–mesenchymal transition pathways
T Ottone, G Silvestrini, R Piazza, S Travaglini… - Leukemia, 2023 - nature.com
Extramedullary (EM) colonization is a rare complication of acute myeloid leukemia (AML),
occurring in about 10% of patients, but the processes underlying tissue invasion are not …
occurring in about 10% of patients, but the processes underlying tissue invasion are not …
Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?
FS Alves-Hanna, JA Crespo-Neto… - Journal of …, 2023 - Wiley Online Library
Inflammation is a physiological mechanism of the immune response and has an important
role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the …
role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the …
Effects of Combinatory In Vitro Treatment with Immune Checkpoint Inhibitors and Cytarabine on the Anti-Cancer Immune Microenvironment in De Novo AML Patients
Ł Bołkun, A Starosz, A Krętowska-Grunwald, T Wasiluk… - Cancers, 2024 - mdpi.com
Simple Summary Immune checkpoint inhibitors'(ICIs) therapeutic use remains a challenge in
acute myeloid leukaemia (AML). We revealed the beneficial influence of the ICIs on the anti …
acute myeloid leukaemia (AML). We revealed the beneficial influence of the ICIs on the anti …
Tocilizumab in combination with a standard induction chemotherapy in acute myeloid leukaemia patients (TOCILAM study): a single-centre, single-arm, phase 1 trial
P Peterlin, A Garnier, A Le Bourgeois… - …, 2023 - thelancet.com
Background In acute myeloid leukaemia (AML), interleukin-6 (IL-6) promotes chemo-
resistance and its levels correlate with poor prognosis. IL-6 blockade may represent a …
resistance and its levels correlate with poor prognosis. IL-6 blockade may represent a …