Clinical delivery of circular RNA: lessons learned from RNA drug development

TL Young, KC Wang, AJ Varley, B Li - Advanced drug delivery reviews, 2023 - Elsevier
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …

[HTML][HTML] Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma

H Luo, H Zhang, J Mao, H Cao, Y Tao, G Zhao… - Cell Death & …, 2023 - nature.com
Exosomes, the cell-derived small extracellular vehicles, play a vital role in intracellular
communication by reciprocally transporting DNA, RNA, bioactive protein, chains of glucose …

Emerging digital PCR technology in precision medicine

L Zhang, R Parvin, Q Fan, F Ye - Biosensors and Bioelectronics, 2022 - Elsevier
Digital PCR (dPCR) is built on partitioning reagent to the extent that single template
molecules are amplified and visualized individually, whereby offers higher precision and …

[HTML][HTML] Upconversion nanoparticles for super-resolution quantification of single small extracellular vesicles

G Huang, Y Liu, D Wang, Y Zhu, S Wen, J Ruan, D Jin - ELight, 2022 - Springer
Although small EVs (sEVs) have been used widely as biomarkers in disease diagnosis, their
heterogeneity at single EV level has rarely been revealed. This is because high-resolution …

Bimetallic Metal–Organic Framework Fe/Co-MIL-88(NH2) Exhibiting High Peroxidase-like Activity and Its Application in Detection of Extracellular Vesicles

Q Jiang, Y Xiao, AN Hong, Z Gao, Y Shen… - … Applied Materials & …, 2022 - ACS Publications
Metal–organic frameworks (MOFs) have many attractive features, including tunable
composition, rigid structure, controllable pore size, and large specific surface area, and thus …

[HTML][HTML] Artificial exosomes for translational nanomedicine

YJ Li, JY Wu, J Liu, W Xu, X Qiu, S Huang… - Journal of …, 2021 - Springer
Exosomes are lipid bilayer membrane vesicles and are emerging as competent
nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges …

Exomeres: A new member of extracellular vesicles family

S Anand, M Samuel, S Mathivanan - New frontiers: Extracellular vesicles, 2021 - Springer
Extracellular vesicles (EVs) are described as membranous vesicles that are secreted by
various cell types. EVs can be categorised as exosomes, ectosomes, apoptotic bodies, large …

[HTML][HTML] Multiplexed profiling of extracellular vesicles for biomarker development

C Jiang, Y Fu, G Liu, B Shu, J Davis, GK Tofaris - Nano-micro letters, 2022 - Springer
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in
molecular trafficking, intercellular transport and the egress of unwanted proteins. They have …

Responsive sensors of upconversion nanoparticles

G Lin, D Jin - ACS sensors, 2021 - ACS Publications
Upconversion nanoparticles are a class of luminescent materials that convert longer-
wavelength near-infrared photons into visible and ultraviolet emissions. They can respond to …

Comparison of curative effect of human umbilical cord-derived mesenchymal stem cells and their small extracellular vesicles in treating osteoarthritis

S Tang, P Chen, H Zhang, H Weng, Z Fang… - International journal …, 2021 - Taylor & Francis
Introduction Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and their
small extracellular vesicles (hUC-MSC-sEVs) have shown attractive prospects applying in …