Many researchers are attempting to identify drugs that can be repurposed as effective
therapies for Alzheimer's disease (AD). Several recent studies have highlighted epidermal …

Malignant gliomas are the most common malignant primary brain tumors and one of the
most challenging forms of cancers to treat. Despite advances in conventional treatment, the …

HER2 kinase inhibitors, such as lapatinib, have demonstrated clinical efficacy in HER2-
amplified breast cancers. By profiling nearly 700 human cancer cell lines, we identified a …

A series of novel pyrazolo [3, 4-d] pyrimidines was synthesised. Twelve synthesised
compounds were evaluated for their anticancer activity against 60 human tumour cell lines …

Abstract A novel series of 2-(3, 6-dimethyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-yloxy)-
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …

We aimed to investigate and compare the effects of erlotinib and gefitinib on UDP-
glucuronosyltransferase (UGT) activities and to quantitatively evaluate their drug-drug …

Kinases control a diverse set of cellular processes comprising of reversible phosphorylation
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …

A novel series of HDAC inhibitors demonstrating class I subtype selectivity and good oral
bioavailability is described. The compounds are potent enzyme inhibitors (IC50 values less …

Protein kinases are key regulators of cellular signaling and play a critical role in
oncogenesis. Inhibitors of protein kinases are pursued by both industry and academia as a …

This contribution is focused on the preparation of a liposomal drug delivery system of
erlotinib resisting the nebulization process that could be used for local treatment of non …