Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review
B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …
world. It is an incurable process, most often leading to death. This disease is multifactorial …
Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease
Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis
ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
Quinones as neuroprotective agents
Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
Contemporary medicinal chemistry strategies for the discovery and development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors
Z Wang, S Cherukupalli, M Xie, W Wang… - Journal of Medicinal …, 2022 - ACS Publications
Currently, HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a major
component of the highly active anti-retroviral therapy (HAART) regimen. However, the …
component of the highly active anti-retroviral therapy (HAART) regimen. However, the …
Multi-target mechanisms of phytochemicals in Alzheimer's disease: Effects on oxidative stress, neuroinflammation and protein aggregation
J Sharifi-Rad, S Rapposelli, S Sestito… - Journal of Personalized …, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …
Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer's disease
W Liu, L Wu, W Liu, L Tian, H Chen, Z Wu… - European Journal of …, 2022 - Elsevier
Multi-targeted directed ligands (MTDLs) are emerging as promising Alzheimer's disease
(AD) therapeutic possibilities. Coumarin is a multifunctional backbone with extensive …
(AD) therapeutic possibilities. Coumarin is a multifunctional backbone with extensive …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review
Quinazolines are considered as a promising class of bioactive heterocyclic compounds with
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …