Multi experimental and computational studies for DNA and HSA interaction of new nano-scale ultrasound-assisted synthesized Pd (II) complex as a potent anticancer …

M Dehkhodaei, M Sahihi, HA Rudbari… - Journal of Molecular …, 2018 - Elsevier
As for daily increasing mortality rate in world due to the growth of cancer causing agents,
design and synthesis of new compounds with anticancer potential benefits is one of the most …

[HTML][HTML] Multispectroscopic and molecular modeling strategy to explore the interaction of cholest-5-en-7-one with human serum albumin: DFT and Hirshfeld surface …

M Alam - Journal of King Saud University-Science, 2021 - Elsevier
The present study accounts for cholest-5-en-7-one (steroid) synthesis using selenium
dioxide and silica as well as its identification using high-resolution mass spectrometry …

Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro

W Jiang, Q Huang, X Meng, R Rehman… - Journal of Food …, 2023 - Wiley Online Library
Ursolic acid (UA) is a natural triterpene carboxylic acid with an underlying anti‐
hyperlipidemia effect. This study examined the mechanism of interactions of UA with …

Spectroscopic probing of the refolding of an unfolded protein through the formation of mixed-micelles

R Modi, L Khamari, A Nandy, S Mukherjee - Spectrochimica Acta Part A …, 2019 - Elsevier
We report the unfolding of the globular protein, Bovine Serum Albumin (BSA) induced by
anionic surfactant sodium dodecyl sulfate (SDS) and subsequently monitored the refolding …

[HTML][HTML] Oxazin-5-ones as a novel class of penicillin binding protein inhibitors: design, synthesis and structure activity relationship

EA Onoabedje, A Ibezim, SN Okafor, US Onoabedje… - PloS one, 2016 - journals.plos.org
Penicillin binding proteins (PBPs) are normal constituents of bacterial which are absent in
mammalian cells. The theoretical binding modes of known oxazin-5-ones toward the protein …

Synthesis, spectral characterization and DNA interactions of 5-(4-substituted phenyl)-1, 3, 4-thiadiazol-2-amine scaffolds

N Shivakumara, PM Krishna - Journal of Molecular Structure, 2020 - Elsevier
Abstract Five 5-(4-Substituted phenyl)-1, 3, 4-thiadiazole-2-amines have been prepared and
structure of the compounds confirmed by spectroscopy studies. On the basis of …

Effects of selected two noble metal ions in medicine on the structure and activity of bovine serum albumin: a multi-spectral studies

H Zhang, M Zhang, Y Wang, Y Wang, S Sun, Z Fei… - Journal of …, 2018 - Elsevier
In the present study, the toxic influence of two metallic ions on serum albumin was studied
by using fluorescence, UV/vis, circular dichroism spectroscopy, and molecular docking, with …

Study on the interaction of amprolium HCl and dinitolmide in animal-derived food products with BSA by multiple spectroscopies and molecular modeling techniques

X Sun, S Bi, J Wu, R Zhao - Journal of Biomolecular Structure and …, 2019 - Taylor & Francis
The coccidiosis, a widespread intestinal parasitic disease caused by protozoa of the genus
Eimeria, remains the most important threat to the economical efficacy of poultry production …

Study of the Interaction Between Coenzyme Q10 and Human Serum Albumin: Spectroscopic Approach

X Peng, Y Sun, W Qi, R Su, Z He - Journal of Solution Chemistry, 2014 - Springer
UV–vis absorption, fluorescence, circular dichroism (CD) and Fourier transform infrared (FT-
IR) spectroscopic methods were employed to reveal the mechanism of the binding between …

Comprehensive insight into the molecular interaction of an anticancer drug-ifosfamide with human alpha-2-macroglobulin: biophysical and in silico studies

MK Zia, T Siddiqui, H Ahsan… - Journal of Biomolecular …, 2022 - Taylor & Francis
Ifosfamide is an active alkylating chemotherapeutic drug chemically related to nitrogen
mustard. The pharmacokinetics of drugs is affected upon binding with protein, making the …