Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment

P Schilrreff, U Alexiev - International journal of molecular sciences, 2022 - mdpi.com
Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to
immune regulation. The dysregulation of the immune system leads to continuing …

Targeting matrix metalloproteases in diabetic wound healing

J Chen, S Qin, S Liu, K Zhong, Y Jing, X Wu… - Frontiers in …, 2023 - frontiersin.org
Chronic inflammation participates in the progression of multiple chronic diseases, including
obesity, diabetes mellitus (DM), and DM related complications. Diabetic ulcer, characterized …

Curcumin-loaded macrophage-derived exosomes effectively improve wound healing

D Li, C Zhang, Z Gao, N Xia, C Wu, C Liu… - Molecular …, 2023 - ACS Publications
This study aims to investigate the potential therapeutic effect of exosomes derived from
macrophages loaded with curcumin (Exos-cur) on the healing of diabetic wounds. As a new …

Berberine encapsulated lecithin–chitosan nanoparticles as innovative wound healing agent in type II diabetes

DS Panda, HM Eid, MH Elkomy, A Khames… - Pharmaceutics, 2021 - mdpi.com
The aim of this research is to formulate a lecithin–chitosan based nanoparticulate system
loaded with berberine (BER-LC-CTS-NPs) that could be integrated into a topically applied …

Regulatory role of Nrf2 signaling pathway in wound healing process

I Süntar, S Çetinkaya, E Panieri, S Saha, B Buttari… - Molecules, 2021 - mdpi.com
Wound healing involves a series of cellular events in damaged cells and tissues initiated
with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in …

[HTML][HTML] Deciphering the emerging role of programmed cell death in diabetic wound healing

J Song, K Zhu, H Wang, M Wu, Y Wu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Diabetic wounds are characterized by delayed and incomplete healing. As one of the most
common complications of diabetes, diabetic wounds can be fatal in some cases …

Hydrogel with ROS scavenging effect encapsulates BR@ Zn-BTB nanoparticles for accelerating diabetic mice wound healing via multimodal therapy

JJ Hu, XZ Yu, SQ Zhang, YX Zhang, XL Chen, ZJ Long… - Iscience, 2023 - cell.com
The strategies for eliminating excess reactive oxygen species (ROS) or suppressing
inflammatory responses on the wound bed have proven effective for diabetic wound healing …

Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies

JP Yadav, AK Singh, M Grishina, P Pathak… - …, 2024 - Springer
Diabetes mellitus is a prevalent cause of mortality worldwide and can lead to several
secondary issues, including DWs, which are caused by hyperglycemia, diabetic neuropathy …

Notoginsenoside R1 facilitated wound healing in high‐fat diet/streptozotocin‐induced diabetic rats

G Cao, C Xiang, R Zhou, Y Zhang, H Xu… - Oxidative medicine …, 2022 - Wiley Online Library
Diabetic ulcers bring about high morbidity and mortality in patients and cause a great
economic burden to society as a whole. Since existing treatments cannot fulfil patient …

[HTML][HTML] Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats

J Zhang, R Zhou, L Deng, G Cao, Y Zhang, H Xu… - Biomedicine & …, 2022 - Elsevier
Diabetic ulcer is a challenging complication of diabetes mellitus but current treatments
cannot achieve satisfactory results. In this study, the effect of Huangbai liniment (HB) and …