This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

This review is part of a special issue dedicated to Opioid addiction, and examines the
influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake …

Metabolic hormones stabilize brain reward and motivational circuits, whereas excessive
opioid consumption counteracts this effect and may impair metabolic function. Here we …

Background Excessive consumption of opioids is associated with impaired metabolic
function including increased body mass index (BMI). Opioid antagonist naltrexone (NTX) is …

Antipsychotics are the most important treatment for schizophrenia. However, antipsychotics,
particularly olanzapine and clozapine, are associated with severe weight gain/obesity side …

Background: Olanzapine, regarded as one of the most efficacious antipsychotic medications
for the treatment of schizophrenia, is associated with a high risk of weight gain and …

Olanzapine is one of the most effective medicines available for stabilizing schizophrenia
spectrum disorders. However, it has been reported to show the greatest propensity for …

Olanzapine (OLZ), a commonly prescribed second generation antipsychotic drug, is
associated with obesity and metabolic syndrome and may contribute to increased …

Background The endogenous opioid system affects metabolism, including weight regulation.
Evidence from preclinical and clinical studies provides a rationale for targeting this system to …

Functional elucidation of the endogenous opioid system temporally paralleled the creation
and growth of the journal, Peptides, under the leadership of its founding editor, Dr. Abba …