Solid organ transplantation (SOT) has emerged from an experimental approach in the 20 th
century to now being an established and practical definitive treatment option for patients with …

Covalent organic frameworks (COFs) are porous organic polymeric materials that are
composed of organic elements and linked together by the thermodynamically stable …

Dendritic cells (DCs) rely on glycolysis for their energy needs to induce pro-inflammatory
antigen-specific immune responses. Therefore, inhibiting DC glycolysis, while presenting …

The ability to alter antigen specificity by T-cell receptor (TCR) or chimeric antigen receptor
(CAR) gene transfer has facilitated personalized cellular immune therapies in cancer …

Use of biomaterials to spatiotemporally control the activation of immune cells is at the
forefront of biomedical engineering research. As more biomaterial strategies are employed …

Considering the substantial role played by dendritic cells (DCs) in the immune system to
bridge innate and adaptive immunity, studies on DC-mediated immunity toward biomaterials …

We developed a novel poly (lactic-co-glycolic acid)-based, microparticle (MP) system
providing concurrent delivery of multiple encapsulated immuno-suppressive factors and …

Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …

Allogeneic islet transplantation is a promising cell-based therapy for Type 1 Diabetes (T1D).
The long-term efficacy of this approach, however, is impaired by allorejection. Current …

Antigen specificity is a primary goal in developing curative therapies for autoimmune
disease. Dendritic cells (DCs), as the most effective antigen presenting cells in the body …