Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement
sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests …

Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

The use of animals as models of human physiology is, and has been for many years, an
indispensable tool for understanding the mechanisms of human disease. In Parkinson's …

Slow-wave sleep (SWS) modulation in rodent models of Alzheimer's disease alters
extracellular amyloid burden. In Parkinson's disease (PD), SWS appears to be closely linked …

Polysomnographic studies have been conducted to explore sleep changes in Parkinson's
disease (PD), but the relationships between sleep disturbances and PD are imperfectly …

Importance Disruption in circadian activity rhythms is very common in older adults,
particularly among those with neurodegenerative diseases, including Parkinson disease …

Introduction Cognitive impairment is the hallmark of Alzheimer's disease (AD) and related
dementias. However, motor decline has been recently described as a prodromal state that …

Neurologists nowadays no longer view neurodegenerative diseases, like Parkinson's and
Alzheimer's disease, as single entities, but rather as a spectrum of multifaceted symptoms …