Emerging roles of autophagy and inflammasome in ehrlichiosis

TR Tominello, ERA Oliveira, SS Hussain… - Frontiers in …, 2019 - frontiersin.org
Human monocytic ehrlichiosis (HME) is a potentially life-threatening tick-borne rickettsial
disease (TBRD) caused by the obligate intracellular Gram-negative bacteria, Ehrlichia. Fatal …

Methylsulfonylmethane ameliorates metabolic-associated fatty liver disease by restoring autophagy flux via AMPK/mTOR/ULK1 signaling pathway

D Han, D Kim, H Kim, J Lee, J Lyu, JS Kim… - Frontiers in …, 2023 - frontiersin.org
Introduction: Metabolism-associated fatty liver disease (MAFLD) is a global health concern
because of its association with obesity, insulin resistance, and other metabolic …

Methylsulfonylmethane induces p53 independent apoptosis in HCT-116 colon cancer cells

AZ Karabay, A Koc, T Ozkan, Y Hekmatshoar… - International journal of …, 2016 - mdpi.com
Methylsulfonylmethane (MSM) is an organic sulfur-containing compound which has been
used as a dietary supplement for osteoarthritis. MSM has been shown to reduce oxidative …

[HTML][HTML] Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells

LE Miller - American journal of cardiovascular disease, 2018 - ncbi.nlm.nih.gov
The development of various cardiovascular diseases (CVDs) are associated with chronic
inflammation. Tumor necrosis factor α (TNF-α) is a pro-inflammatory cytokine that activates …

Transungual delivery, anti-inflammatory activity, and in vivo assessment of a cyclodextrin polypseudorotaxanes nail lacquer

F Fernández-Campos, F Navarro, A Corrales, J Picas… - Pharmaceutics, 2020 - mdpi.com
A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl
sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated …

IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene

J Kim, H Ahn, S Yu, JH Ahn, HJ Ko, MN Kweon… - Cytokine, 2020 - Elsevier
Inflammasome activation induces the maturation and secretion of interleukin (IL)-1β and-18,
and is dependent on NF-κB signaling to induce the transcription of the inflammasome …

Methylsulfonylmethane increases the alveolar bone density of mandibles in aging female mice

H Aljohani, LT Senbanjo, M Al Qranei… - Frontiers in …, 2021 - frontiersin.org
Methylsulfonylmethane (MSM) is a naturally occurring anti-inflammatory compound that
effectively treats multiple degenerative diseases such as osteoarthritis and acute …

The role of inflammasomes in atherosclerosis and stroke pathogenesis

D Sarmah, A Datta, S Raut, A Sarkar… - Current …, 2020 - ingentaconnect.com
Inflammation is a devastating outcome of cerebrovascular diseases (CVD), namely stroke
and atherosclerosis. Numerous studies over the decade have shown that inflammasomes …

Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and …

TJ Cirino, AR Alleyne, V Duarte, A Figueroa… - Journal of Neuroimmune …, 2021 - Springer
Despite the success of combined antiretroviral therapy (cART) in reducing viral load, a
substantial portion of Human Immunodeficiency Virus (HIV)+ patients report chronic pain …

Molecular mechanisms of methylsulfonylmethane and allicin in the inhibition of CD44±breast cancer cells growth

E Sarkhani, N Najafzadeh, N Tata, M Dastan… - Journal of functional …, 2017 - Elsevier
Breast carcinoma is a common cause of cancer death in women worldwide. CD44±cells
were isolated from MCF7 cell line by magnetic-activated cell sorting (MACS) and treated …