[PDF][PDF] Focus on colon cancer
SD Markowitz, DM Dawson, J Willis, JKV Willson - Cancer cell, 2002 - cell.com
The colon and rectum comprise the final portion of the human digestive tract, commencing at
the ileocecal valve that marks the end of the small intestine, terminating at the anus, and …
the ileocecal valve that marks the end of the small intestine, terminating at the anus, and …
Molecular diagnostics in colorectal carcinoma: advances and applications for 2018
A Bhalla, M Zulfiqar, MH Bluth - Clinics in laboratory …, 2018 - labmed.theclinics.com
The pathogenesis of colorectal carcinoma is heterogeneous and involves complex multistep
molecular pathways initiated by genetic and epigenetic events. The molecular classification …
molecular pathways initiated by genetic and epigenetic events. The molecular classification …
The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic …
JC Desmond, JC Mountford, MT Drayson, EA Walker… - Cancer research, 2003 - AACR
We and others have demonstrated expression of the aldo-keto reductase AKR1C3 in
myeloid leukemia cell lines and that inhibitors of the enzyme, including nonsteroidal anti …
myeloid leukemia cell lines and that inhibitors of the enzyme, including nonsteroidal anti …
Human lupus T cells resist inactivation and escape death by upregulating COX-2
L Xu, L Zhang, Y Yi, HK Kang, SK Datta - Nature medicine, 2004 - nature.com
Autoimmune T-helper cells drive pathogenic autoantibody production in systemic lupus
erythematosus (SLE), but the mechanisms maintaining those T cells are unknown …
erythematosus (SLE), but the mechanisms maintaining those T cells are unknown …
Crystal Structures of Prostaglandin D2 11-Ketoreductase (AKR1C3) in Complex with the Nonsteroidal Anti-Inflammatory Drugs Flufenamic Acid and Indomethacin
AL Lovering, JP Ride, CM Bunce, JC Desmond… - Cancer research, 2004 - AACR
It is becoming increasingly well established that nonsteroidal anti-inflammatory drugs
(NSAID) protect against tumors of the gastrointestinal tract and that they may also protect …
(NSAID) protect against tumors of the gastrointestinal tract and that they may also protect …
Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells
A Reinacher-Schick, A Schoeneck, U Graeven… - …, 2003 - academic.oup.com
Non-steroidal anti-inflammatory drugs (NSAID) may inhibit colon cancer development
through affecting proliferation and apoptosis. However, their use in cancer chemoprevention …
through affecting proliferation and apoptosis. However, their use in cancer chemoprevention …
Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking
YN Ye, ESL Liu, VY Shin, WKK Wu, CH Cho - Toxicology, 2004 - Elsevier
Our previous study shows that cigarette smoking can promote inflammation-associated
adenoma formation in the mouse colon, but the underling mechanism remains unknown …
adenoma formation in the mouse colon, but the underling mechanism remains unknown …
Non‐steroidal anti‐inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase‐2 protein expression in endometrial cancer cells
J Gao, K Niwa, W Sun, M Takemura, Z Lian… - Cancer …, 2004 - Wiley Online Library
We determined the effects of several non‐steroidal anti‐inflammatory drugs (NSAIDs),
aspirin (acetylsalicylic acid, ASA), indomethacin and a cyclooxygenase‐2 (COX‐2) …
aspirin (acetylsalicylic acid, ASA), indomethacin and a cyclooxygenase‐2 (COX‐2) …
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer …
S Gobec, P Brožič, TL Rižner - Bioorganic & medicinal chemistry letters, 2005 - Elsevier
Nonsteroidal anti-inflammatory drugs (NSAIDs) like indomethacin, flufenamic acid, and
related compounds have been recently identified as potent inhibitors of AKR1C3. We report …
related compounds have been recently identified as potent inhibitors of AKR1C3. We report …
Roles of religious involvement and social support in the risk of colon cancer among Blacks and Whites
This population-based case-control study of Blacks and Whites in North Carolina (1996–
2000) examined the relation between social ties, etiology of colon cancer, and stage of …
2000) examined the relation between social ties, etiology of colon cancer, and stage of …