Carbamazepine-related antiepileptic drugs for the treatment of epilepsy-a comparative review

J Gierbolini, M Giarratano… - Expert opinion on …, 2016 - Taylor & Francis
Carbamazepine (CBZ) is one of the older antiepileptic drugs (AEDs), both in the US and
worldwide. Neurologists and non-neurologists have become very familiar with its spectrum …

Third generation antiepileptic drug monotherapies in adults with epilepsy

M Mula - Expert review of Neurotherapeutics, 2016 - Taylor & Francis
Introduction: Drugs marketed during the last few years (ie Lacosamide, Ruifinamide,
Eslicarbazepine acetate, Brivaracetam and Perampanel) are increasingly regarded as third …

[HTML][HTML] Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Nav1.4 in Its Slow-Inactivated State and Inhibits Sodium Current

CW Huang, PC Lin, JL Chen, MJ Lee - Biomedicines, 2021 - mdpi.com
Cannabidiol (CBD), one of the cannabinoids from the cannabis plant, can relieve the
myotonia resulting from sodium channelopathy, which manifests as repetitive discharges of …

Tolerability and safety of commonly used antiepileptic drugs in adolescents and adults: a clinician's overview

MJ Brodie - CNS drugs, 2017 - Springer
This paper discusses the issues surrounding the tolerability and safety of the commonly
used antiepileptic drugs (AEDs) in adolescents and adults. The content includes dose …

Pharmacodynamics and common drug-drug interactions of the third-generation antiepileptic drugs

S Stefanović, SM Janković, M Novaković… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Anticonvulsants that belong to the third generation are considered as
'newer'antiepileptic drugs, including: eslicarbazepine acetate, lacosamide, perampanel …

[HTML][HTML] Eslicarbazepine acetate as adjunctive therapy for primary generalized tonic-clonic seizures in adults: a prospective observational study

Y Winter, K Sandner, TL Vieth, N Melzer, S Klimpe… - CNS drugs, 2022 - Springer
Background Eslicarbazepine acetate (ESL), a novel sodium channel blocker, is approved for
mono and adjunctive treatment of partial epileptic seizures with or without secondary …

Practical guidance and considerations for transitioning patients from oxcarbazepine or carbamazepine to eslicarbazepine acetate—Expert opinion

J Peltola, M Holtkamp, R Rocamora, P Ryvlin… - Epilepsy & Behavior, 2015 - Elsevier
There is currently a lack of guidance on methodology and special considerations for
transitioning patients from oxcarbazepine (OXC) or carbamazepine (CBZ) to …

Eslicarbazepine acetate add‐on therapy for drug‐resistant focal epilepsy

XC Chang, H Yuan, Y Wang, HQ Xu… - Cochrane Database …, 2021 - cochranelibrary.com
Eslicarbazepine acetate add‐on therapy for drug‐resistant focal epilepsy - Chang, XC - 2021 |
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Practical use of newer antiepileptic drugs as adjunctive therapy in focal epilepsy

MJ Brodie - CNS drugs, 2015 - Springer
This article lays the background for, and discusses the practical issues surrounding, the
adjunctive use of the last four antiepileptic drugs (AEDs) to be licensed for the treatment of …

Inhibition of neuronal Na+ currents by lacosamide: Differential binding affinity and kinetics to different inactivated states

YS Peng, HT Wu, YC Lai, JL Chen, YC Yang… - Neuropharmacology, 2020 - Elsevier
Lacosamide is a new-generation anticonvulsant acting on Na+ channels. Compared to the
classic anticonvulsants targeting Na+ channels, lacosamide is unique in structure and in its …