Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

UB Pandey, CD Nichols - Pharmacological reviews, 2011 - ASPET
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Drosophila neuropeptides in regulation of physiology and behavior

DR Nässel, ÅME Winther - Progress in neurobiology, 2010 - Elsevier
Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …

Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity

Z Mao, RL Davis - Frontiers in neural circuits, 2009 - frontiersin.org
We examined tyrosine hydroxylase (TH-GAL4) expression and anti-TH immunoreactivity in
the Drosophila protocerebrum and characterized single cell clones of the TH-GAL4 neurons …

Dopamine reveals neural circuit mechanisms of fly memory

S Waddell - Trends in neurosciences, 2010 - cell.com
A goal of memory research is to understand how changing the weight of specific synapses in
neural circuits in the brain leads to an appropriate learned behavioral response. Finding the …

The neurobiological basis of sleep: Insights from Drosophila

S Ly, AI Pack, N Naidoo - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
Sleep is a biological enigma that has raised numerous questions about the inner workings
of the brain. The fundamental question of why our nervous systems have evolved to require …

The Neurotransmitters Involved in Drosophila Alcohol-Induced Behaviors

MM Chvilicek, I Titos, A Rothenfluh - Frontiers in behavioral …, 2020 - frontiersin.org
Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Aggression in Drosophila.

EA Kravitz, MP Fernandez - Behavioral neuroscience, 2015 - psycnet.apa.org
Aggression is used by essentially all species of animals to gain access to desired resources,
including territory, food, and potential mates: Fruit flies are no exception. In Drosophila, both …

Developmental analysis of the dopamine‐containing neurons of the Drosophila brain

V Hartenstein, L Cruz, JK Lovick… - Journal of Comparative …, 2017 - Wiley Online Library
ABSTRACT The Drosophila dopaminergic (DAergic) system consists of a relatively small
number of neurons clustered throughout the brain and ventral nerve cord. Previous work …

[HTML][HTML] Exposure to atrazine alters behaviour and disrupts the dopaminergic system in Drosophila melanogaster

FH Figueira, N de Quadros Oliveira… - … and Physiology Part C …, 2017 - Elsevier
Atrazine is an extensively used herbicide, and has become a common environmental
contaminant. Effects on dopaminergic neurotransmission in mammals following exposure to …

Of fighting flies, mice, and men: are some of the molecular and neuronal mechanisms of aggression universal in the animal kingdom?

AL Thomas, SM Davis, HA Dierick - PLoS genetics, 2015 - journals.plos.org
Aggressive behavior is widespread in the animal kingdom, but the degree of molecular
conservation between distantly related species is still unclear. Recent reports suggest that at …