Epigenetic mechanisms in drug relapse

CT Werner, RD Altshuler, Y Shaham, X Li - Biological Psychiatry, 2021 - Elsevier
A growing body of evidence from the past 15 years implicates epigenetic mechanisms in the
behavioral effects of addictive drugs. The main focus of these studies has been epigenetic …

Recent advances in exhaled breath sample preparation technologies for drug of abuse detection

F Xu, J Zhou, H Yang, L Chen, J Zhong, Y Peng… - TrAC Trends in …, 2022 - Elsevier
This current review focuses on contributions to exhaled breath (EB) preparation in drug of
abuse (DOA) detection. DOA has caused health hazards, accidents, criminal acts and huge …

[HTML][HTML] Histone H3 dopaminylation in nucleus accumbens, but not medial prefrontal cortex, contributes to cocaine-seeking following prolonged abstinence

AF Stewart, AE Lepack, SL Fulton, P Safovich… - Molecular and Cellular …, 2023 - Elsevier
Enduring patterns of epigenomic and transcriptional plasticity within the mesolimbic
dopamine system contribute importantly to persistent behavioral adaptations that …

[HTML][HTML] DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex

E Poisel, L Zillich, F Streit, J Frank, MM Friske… - Frontiers in …, 2023 - frontiersin.org
Background Cocaine use disorder (CUD) is characterized by a loss of control over cocaine
intake and is associated with structural, functional, and molecular alterations in the human …

[HTML][HTML] Glucocorticoid receptor-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction

SH Duttke, P Montilla-Perez, MW Chang, H Li… - Frontiers in …, 2022 - frontiersin.org
Substance abuse and addiction represent a significant public health problem that impacts
multiple dimensions of society, including healthcare, the economy, and the workforce. In …

The roles of the circadian hormone melatonin in drug addiction

S Jia, X Guo, Z Chen, S Li, X Liu - Pharmacological Research, 2022 - Elsevier
Given the devastating social and health consequences of drug addiction and the limitations
of current treatments, a new strategy is needed. Circadian system disruptions are frequently …

Why haven't we solved the addiction crisis?

K Blum, A Bowirrat, LL Gomez, BW Downs… - Journal of the …, 2022 - Elsevier
The current addiction crisis has destroyed a multitude of lives, leaving millions of fatalities
worldwide in its wake. At the same time, various governmental agencies dedicated to …

Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders

BJ Lopresti, SK Royse, CA Mathis… - Journal of …, 2023 - Wiley Online Library
With the emergence of positron emission tomography (PET) in the late 1970s, psychiatry
had access to a tool capable of non‐invasive assessment of human brain function. Early …

Oxytocin prevents cue‐induced reinstatement of oxycodone seeking: Involvement of DNA methylation in the hippocampus

XY Fan, G Shi, XJ He, XY Li, YX Wan… - Addiction Biology, 2021 - Wiley Online Library
Oxycodone is one of the most commonly used analgesics in the clinic. However, long‐term
use can contribute to drug dependence. Accumulating evidence of changes in DNA …

[HTML][HTML] Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats

B Miao, X Xing, V Bazylianska, P Madden… - Communications …, 2023 - nature.com
Psychostimulant methamphetamine (METH) is neurotoxic to the brain and, therefore, its
misuse leads to neurological and psychiatric disorders. The gene regulatory network (GRN) …