Claudin-1 mediated tight junction dysfunction as a contributor to atopic march

Y Xia, H Cao, J Zheng, L Chen - Frontiers in Immunology, 2022 - frontiersin.org
Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy
tends to increase after atopic dermatitis. The mechanism underlying the progression of …

Interferon‐γ downregulates tight junction function, which is rescued by interleukin‐17A

Y Mizutani, N Takagi, H Nagata… - Experimental …, 2021 - Wiley Online Library
Although atopic dermatitis (AD) has been reported to be a typical type 2 immune response
disease, it is also an inflammatory skin disease that involves cytokines, such as Th1, Th17 …

The role of tight junctions in atopic dermatitis: a systematic review

S Katsarou, M Makris, E Vakirlis… - Journal of Clinical …, 2023 - mdpi.com
Background: Tight junctions are transmembrane proteins that regulate the permeability of
water, solutes including ions, and water-soluble molecules. The objective of this systematic …

Effects of mucopolysaccharide polysulphate on tight junction barrier in human epidermal keratinocytes

M Fujikawa, H Sugimoto, R Tamura… - Experimental …, 2022 - Wiley Online Library
Tight junctions (TJs) play important roles in epidermal barrier function and their dysfunction
is involved in the pathogenesis of various skin diseases, including atopic dermatitis (AD) …

The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin …

M Haftek, V Oji, L Feldmeyer, D Hohl… - International journal of …, 2022 - mdpi.com
We evaluated the presence of tight junction (TJ) remnants in the stratum corneum (SC) of in
vitro reconstructed human epidermis and human skin explants subjected or not to an …

The role of cell adhesion molecule 1 (CADM1) in cutaneous malignancies

Y Sawada, E Mashima, N Saito-Sasaki… - International journal of …, 2020 - mdpi.com
Cell adhesion ability is one of the components to establish cell organization and shows a
great contribution to human body construction consisting of various types of cells mixture to …

CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders

KA Arnold, MC Moran, H Shi… - Experimental …, 2024 - Wiley Online Library
The transmembrane protein claudin‐1 is critical for formation of the epidermal barrier
structure called tight junctions (TJ) and has been shown to be important in multiple disease …

Autosomal recessive congenital ichthyosis caused by a pathogenic missense variant in CLDN1

J Mohamad, L Samuelov, S Assaf… - American Journal of …, 2022 - Wiley Online Library
Autosomal recessive congenital ichthyosis (ARCI) refers to a large and genetically
heterogenous group of non‐syndromic disorders of cornification featuring diffuse scaling …

Effect of zeolite supplementation on gene expression in the intestinal mucosa in the context of immunosafety support in poultry

A Dunislawska, J Biesek, M Banaszak, M Siwek… - Genes, 2022 - mdpi.com
Zeolite is an effective and non-toxic silicate mineral. Its properties are widely used in industry
due to its sorption and ion exchange properties. Due to its excellent chemical properties, it …

Gut Bacterial Community Determines the Therapeutic Effect of Ginsenoside on Canine Inflammatory Bowel Disease by Modulating the Colonic Mucosal Barrier

A Mao, W Zhao, Y Zhu, F Kong, D Chen, H Si, C Xu - Microorganisms, 2023 - mdpi.com
Inflammatory bowel disease (IBD) comprises systemic inflammatory conditions primarily
affecting the gastrointestinal tract, including Crohn's disease and ulcerative colitis. This …