Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

YQ He, CC Zhou, LY Yu, L Wang, J Deng… - Pharmacological …, 2021 - Elsevier
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome
(ARDS) as common life-threatening lung diseases with high mortality rates are mostly …

An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: insights into molecular mechanisms

B Dinda, M Dinda, S Dinda, UC De - European Journal of Medicinal …, 2023 - Elsevier
Abstract The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is highly contagious …

[HTML][HTML] Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

H Lv, Q Liu, Z Wen, H Feng, X Deng, X Ci - Redox biology, 2017 - Elsevier
Abundant natural flavonoids can induce nuclear factor-erythroid 2 related factor 2 (Nrf2)
and/or AMP-activated protein kinase (AMPK) activation, which play crucial roles in the …

[HTML][HTML] Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating …

H Lv, Z Yu, Y Zheng, L Wang, X Qin… - International journal of …, 2016 - ncbi.nlm.nih.gov
Oxidative damage and inflammation are closely associated with the pathogenesis of acute
lung injury (ALI). Thus, we explored the protective effect of isovitexin (IV), a …

[HTML][HTML] The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups

AR Zuo, HH Dong, YY Yu, QL Shu, LX Zheng, XY Yu… - Chinese medicine, 2018 - Springer
Background Compounds with the ability to scavenge reactive oxygen species (ROS) and
inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases …

The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state

W Jiang, F Luo, Q Lu, J Liu, P Li, X Wang, Y Fu… - Chemico-biological …, 2016 - Elsevier
Inflammation response and oxidative stress have been reported to be involved in the
pathogenesis of acute lung injury (ALI). Accordingly, anti-inflammatory treatment is proposed …

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

M Battino, F Giampieri, F Pistollato, A Sureda… - Biotechnology …, 2018 - Elsevier
Organisms are constantly exposed to a broad range of pathological and stress-inducing
agents, allergens and environmental chemicals that can induce infections, toxicity or other …

Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS‐CoV‐2

A Gour, D Manhas, S Bag, B Gorain… - Phytotherapy …, 2021 - Wiley Online Library
Emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection,
COVID‐19, has become the global panic since December 2019, which urges the global …

Proinflammatory pathways: the modulation by flavonoids

D Ribeiro, M Freitas, JLFC Lima… - Medicinal research …, 2015 - Wiley Online Library
Inflammation is a natural, carefully orchestrated response of the organism to tissue damage,
involving various signaling systems and the recruitment of inflammatory cells. These cells …

[HTML][HTML] Baicalein, a bioflavonoid, prevents cisplatin-induced acute kidney injury by up-regulating antioxidant defenses and down-regulating the MAPKs and NF-κB …

BD Sahu, JM Kumar, R Sistla - PloS one, 2015 - journals.plos.org
Acute renal failure is a serious complication of the anticancer drug cisplatin. The potential
role of baicalein, a naturally occurring bioflavonoid on cisplatin-induced renal injury is …