Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …

Organoids bridge the gap between 2D cell lines and in vivo studies. With their 3D
organization and cellular heterogeneity, adult stem cell-derived organoids closely resemble …

Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary
tree. CCA has a poor prognosis, its clinical management remains challenging, and effective …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and developing therapies. Here, we review …

Transcription factor binding across the genome is regulated by DNA sequence and
chromatin features. However, it is not yet possible to quantify the impact of chromatin context …

Patient-derived tumor organoids have been established as promising tools for in vitro
modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are …

Cancer is one of the most leading causes of death and a major public health problem,
universally. According to accumulated data, annually, approximately 8.5 million people died …

Nowadays, the diagnosis and treatment system of malignant tumors has increasingly tended
to be more precise and personalized. And the existing tumor models are still unable to fully …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

TP53 R249S mutation in hepatic organoids captures the predis... : Hepatology TP53 R249S
mutation in hepatic organoids captures the predisposing cancer risk : Hepatology AASLD …