Ovarian cancer is the most common malignant tumors of the female reproductive system,
and its standard treatments are cytoreductive surgery and platinum-based adjuvant …

Metabolic (dysfunction) associated fatty liver disease (MAFLD) is one of the most prevalent
liver diseases and has no approved therapeutics. The high failure rates witnessed in late …

Understanding the development, regeneration, and disorders of the liver is the major goal in
liver biology. Current mechanistic knowledge of human livers has been largely derived from …

Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and
cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality …

Adult stem cells are responsible for homoeostasis and regeneration of epithelial tissues.
Stem cell function is regulated by both cell autonomous mechanisms as well as the niche …

Organoids are three-dimensional, multicellular constructs that recapitulate the structural and
functional features of specific organs. Because of these characteristics, organoids have …

Liver diseases affect hundreds of millions of people worldwide; most often the hepatocytes
or cholangiocytes are damaged. Diseases of the biliary tract cause severe patient burden …

Optimization of cell engineering protocols requires standard, comprehensive quality metrics.
We previously developed CellNet, a computational tool to quantitatively assess the …

Gastric cancer (GC) is one of the most frequent and lethal malignancies in the world.
However, our understanding of the mechanisms underlying its initiation and progression is …

FBXW7 is an E3 ubiquitin ligase that targets proteins for proteasome-mediated degradation
and is mutated in various cancer types. Here, we use CRISPR base editors to introduce …