Hepatocellular carcinoma is one of the malignancies worldwide with a high mortality rate
and an increasing incidence. Molecular Targeted agents are its common first-line treatment …

Organoids are three-dimensional, functional structures that mimic in vivo organs. They offer
new opportunities for the modeling of cancer and infectious and rare hereditary diseases …

Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies
are required for drug discovery and development to reduce the gap between the results of …

Deubiquitinases (DUBs) have been the subject of intense scrutiny in recent years. Many of
their diverse enzymatic mechanisms are well characterized in vitro; however, our …

As genomic analysis technology has advanced, it has become possible to sub-classify
intrahepatic cholangiocarcinoma (ICC) at the histological or molecular level. Here, we verify …

Adult stem cells are responsible for homoeostasis and regeneration of epithelial tissues.
Stem cell function is regulated by both cell autonomous mechanisms as well as the niche …

The biology of aging is focused on the identification of novel pathways that regulate the
underlying processes of aging to develop interventions aimed at delaying the onset and …

Cancer accounted for almost ten million deaths worldwide in 2020. Metastasis,
characterized by cancer cell invasion to other parts of the body, is the main cause of cancer …

The liver executes 500+ functions, such as protein synthesis, xenobiotic metabolism, bile
production, and metabolism of carbohydrates/fats/proteins. Such functions can be severely …

Patient-derived organoids (PDOs) have emerged as a promising platform for clinical and
translational studies. A strong correlation exists between clinical outcomes and the use of …