PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

[PDF][PDF] A systematic review of animal models of NAFLD finds high‐fat, high‐fructose diets most closely resemble human NAFLD

YR Im, H Hunter, D de Gracia Hahn, A Duret… - …, 2021 - Wiley Online Library
Background and Aims Animal models of human disease are a key component of
translational hepatology research, yet there is no consensus on which model is optimal for …

Saroglitazar, a PPAR‐α/γ agonist, for treatment of NAFLD: a randomized controlled double‐blind phase 2 trial

S Gawrieh, M Noureddin, N Loo, R Mohseni… - …, 2021 - Wiley Online Library
Background and Aims NAFLD is characterized by insulin resistance and dysregulated lipid
and glucose metabolism. Saroglitazar, a dual peroxisome proliferator activated receptor‐α/γ …

[HTML][HTML] Antioxidant peptides from monkfish swim bladders: ameliorating NAFLD in vitro by suppressing lipid accumulation and oxidative stress via regulating AMPK …

MF Wu, QH Xi, Y Sheng, YM Wang, WY Wang, CF Chi… - Marine drugs, 2023 - mdpi.com
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8),
DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on …

[HTML][HTML] The role of tumor necrosis factor-alpha in the pathogenesis and treatment of nonalcoholic fatty liver disease

ID Vachliotis, SA Polyzos - Current obesity reports, 2023 - Springer
Abstract Purpose of Review To summarize experimental and clinical evidence on the
association between tumor necrosis factor-α (TNF-α) and nonalcoholic fatty liver disease …

Retracted: M2 Macrophage–Derived Exosomes Facilitate HCC Metastasis by Transferring αMβ2 Integrin to Tumor Cells

J Wu, W Gao, Q Tang, Y Yu, W You, Z Wu, Y Fan… - …, 2021 - Wiley Online Library
Background and Aims The development and progression of hepatocellular carcinoma
(HCC) is dependent on its local microenvironment. Tumor‐associated macrophages (TAMs) …

[HTML][HTML] Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

T Puengel, H Liu, A Guillot, F Heymann… - International journal of …, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …

[HTML][HTML] Current options and future directions for NAFLD and NASH treatment

C Zhang, M Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …

[HTML][HTML] The effects of probiotics on small intestinal microbiota composition, inflammatory cytokines and intestinal permeability in patients with non-alcoholic fatty liver …

N Ayob, KN Muhammad Nawawi, MH Mohamad Nor… - Biomedicines, 2023 - mdpi.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) has soared globally. As our
understanding of the disease grows, the role of the gut-liver axis (GLA) in NAFLD …

[HTML][HTML] PPAR-targeted therapies in the treatment of non-alcoholic fatty liver disease in diabetic patients

NF Lange, V Graf, C Caussy, JF Dufour - International journal of …, 2022 - mdpi.com
Peroxisome proliferator-activated receptors (PPAR), ligand-activated transcription factors of
the nuclear hormone receptor superfamily, have been identified as key metabolic regulators …