Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk
of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an …

PURPOSE To prospectively examine the association between clonal hematopoiesis (CH)
and subsequent risk of lung cancer. METHODS Among 200,629 UK Biobank (UKBB) …

Advances in population-scale genomic sequencing have greatly expanded the
understanding of the inherited basis of cardiovascular disease (CVD). Reanalysis of these …

Clonal hematopoiesis driven by DNMT3A and TET2 mutations: ro... : Current Opinion in
Hematology Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in …

The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of
hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy …

BACKGROUND: Clonal hematopoiesis (CH), which results from an array of nonmalignant
driver gene mutations, can lead to altered immune cell function and chronic disease, and …

ABSTRACT Rationale and Objective Clonal hematopoiesis of indeterminate potential
(CHIP), defined by the age-related ontogenesis of expanded leukemogenic mutations …

Aims Cardiogenic shock (CS) with variable systemic inflammation may be responsible for
patient heterogeneity and the exceedingly high mortality rate. Cardiovascular events have …