[HTML][HTML] Drug repurposing: An effective strategy to accelerate contemporary drug discovery
Because of the high risk, substantial cost and slow pace of new drug discovery and
development, drug repurposing (also called repositioning, redirecting, reprofiling) is …
development, drug repurposing (also called repositioning, redirecting, reprofiling) is …
Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2
MS Bekheit, SS Panda, AS Girgis - European Journal of Medicinal …, 2023 - Elsevier
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …
[HTML][HTML] SARS-CoV-2 proteases Mpro and PLpro: Design of inhibitors with predicted high potency and low mammalian toxicity using artificial neural networks, ligand …
RS Tumskiy, AV Tumskaia, IN Klochkova… - Computers in Biology …, 2023 - Elsevier
The main (Mpro) and papain-like (PLpro) proteases are highly conserved viral proteins
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …
[HTML][HTML] Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment
H Que, W Hong, T Lan, H Zeng, L Chen… - Signal transduction and …, 2022 - nature.com
Abstract For coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), 15–30% of patients are likely to develop COVID-19 …
syndrome coronavirus 2 (SARS-CoV-2), 15–30% of patients are likely to develop COVID-19 …
[HTML][HTML] Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion …
P Straková, P Bednář, J Kotouček, J Holoubek… - Virus Research, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel …
[HTML][HTML] Exploring nanoselenium to tackle mutated SARS-CoV-2 for efficient COVID-19 management
Despite ongoing public health measures and increasing vaccination rates, deaths and
disease severity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
disease severity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Advancing drug repurposing research: trends, collaborative networks, innovation and knowledge leaders
Highlights•The advancement of drug repurposing (DR) relies on scientific leadership and
innovative institutions with access to knowledge.•A bibliometric review and a social network …
innovative institutions with access to knowledge.•A bibliometric review and a social network …
[HTML][HTML] Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification
S Kari, A Murugesan, R Thiyagarajan, S Kidambi… - Biomedicine & …, 2023 - Elsevier
Glioblastoma Multiforme (GBM) is known to be by far the most aggressive brain tumor to
affect adults. The median survival rate of GBM patient's is< 15 months, while the GBM cells …
affect adults. The median survival rate of GBM patient's is< 15 months, while the GBM cells …
[HTML][HTML] Quantitative analysis of two COVID-19 antiviral agents, favipiravir and remdesivir, in spiked human plasma using spectrophotometric methods; greenness …
AS Batubara, AH Abdelazim, AA Almrasy, M Gamal… - BMC chemistry, 2023 - Springer
Favipiravir and remdesivir have been included in the COVID-19 treatment guidelines panel
of several countries. The main objective of the current work is to develop the first validated …
of several countries. The main objective of the current work is to develop the first validated …
Review and perspective on bioinformatics tools using machine learning and deep learning for predicting antiviral peptides
Viruses constitute a constant threat to global health and have caused millions of human and
animal deaths throughout human history. Despite advances in the discovery of antiviral …
animal deaths throughout human history. Despite advances in the discovery of antiviral …