[HTML][HTML] Drug repurposing: An effective strategy to accelerate contemporary drug discovery

P Zhan, B Yu, L Ouyang - Drug discovery today, 2022 - ncbi.nlm.nih.gov
Because of the high risk, substantial cost and slow pace of new drug discovery and
development, drug repurposing (also called repositioning, redirecting, reprofiling) is …

Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2

MS Bekheit, SS Panda, AS Girgis - European Journal of Medicinal …, 2023 - Elsevier
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for
human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of …

[HTML][HTML] SARS-CoV-2 proteases Mpro and PLpro: Design of inhibitors with predicted high potency and low mammalian toxicity using artificial neural networks, ligand …

RS Tumskiy, AV Tumskaia, IN Klochkova… - Computers in Biology …, 2023 - Elsevier
The main (Mpro) and papain-like (PLpro) proteases are highly conserved viral proteins
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …

[HTML][HTML] Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment

H Que, W Hong, T Lan, H Zeng, L Chen… - Signal transduction and …, 2022 - nature.com
Abstract For coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), 15–30% of patients are likely to develop COVID-19 …

[HTML][HTML] Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion …

P Straková, P Bednář, J Kotouček, J Holoubek… - Virus Research, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted great interest in novel …

[HTML][HTML] Exploring nanoselenium to tackle mutated SARS-CoV-2 for efficient COVID-19 management

A Singh, P Singh, R Kumar, A Kaushik - Frontiers in Nanotechnology, 2022 - frontiersin.org
Despite ongoing public health measures and increasing vaccination rates, deaths and
disease severity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Advancing drug repurposing research: trends, collaborative networks, innovation and knowledge leaders

PC Albuquerque, F Zicker, BP Fonseca - Drug Discovery Today, 2022 - Elsevier
Highlights•The advancement of drug repurposing (DR) relies on scientific leadership and
innovative institutions with access to knowledge.•A bibliometric review and a social network …

[HTML][HTML] Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification

S Kari, A Murugesan, R Thiyagarajan, S Kidambi… - Biomedicine & …, 2023 - Elsevier
Glioblastoma Multiforme (GBM) is known to be by far the most aggressive brain tumor to
affect adults. The median survival rate of GBM patient's is< 15 months, while the GBM cells …

[HTML][HTML] Quantitative analysis of two COVID-19 antiviral agents, favipiravir and remdesivir, in spiked human plasma using spectrophotometric methods; greenness …

AS Batubara, AH Abdelazim, AA Almrasy, M Gamal… - BMC chemistry, 2023 - Springer
Favipiravir and remdesivir have been included in the COVID-19 treatment guidelines panel
of several countries. The main objective of the current work is to develop the first validated …

Review and perspective on bioinformatics tools using machine learning and deep learning for predicting antiviral peptides

N Lefin, L Herrera-Belén, JG Farias, JF Beltrán - Molecular Diversity, 2023 - Springer
Viruses constitute a constant threat to global health and have caused millions of human and
animal deaths throughout human history. Despite advances in the discovery of antiviral …