Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many
immune cells. Despite extensive research into its function in numerous disorders, a thorough …

Meningeal lymphatic vessels (MLVs) promote tissue clearance and immune surveillance in
the central nervous system (CNS). Vascular endothelial growth factor-C (VEGF-C) regulates …

Sepsis induces immune alterations, which last for months after the resolution of illness. The
effect of this immunological reprogramming on the risk of developing cancer is unclear. Here …

Hepatic insulin resistance is recognized as a driver of type 2 diabetes and fatty liver disease
but specific therapies are lacking. Here we explore the potential of human induced …

Abstract Post-acute COVID-19 (PACS) are associated with cardiovascular dysfunction,
especially postural orthostatic tachycardia syndrome (POTS). Patients with PACS, both in …

The liver is a key metabolic organ that maintains whole‐body nutrient homeostasis. Aging‐
induced liver function alterations contribute to systemic susceptibility to aging‐related …

Appropriate responses to inflammation are conducive to pathogen elimination and tissue
repair, while uncontrolled inflammatory reactions are likely to result in the damage of tissues …

Hepatocyte damage during liver injury instigates activation of macrophages and hepatic
stellate cells (HSCs) resulting in liver inflammation and fibrosis respectively. Improving …

Purpose: Vitiligo is a T cell-mediated skin depigmentation disease. Though treatments
arresting disease progression and inducing repigmentation are available, the efficacy of …