The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

The concept that G protein‐coupled receptors (GPCRs) can form hetero‐dimers or hetero‐
oligomers continues to gain experimental support. However, with the exception of the …

Plasticity of excitatory synapses onto striatal projection neurons (MSNs) has the potential to
regulate motor function by setting the gain on signals driving both direct-and indirect …

Parkinson disease (PD) is no longer considered a complex motor disorder characterized by
parkinsonism but rather a systemic disease with variegated non-motor deficits and …

Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and
inhibitory neurotransmission. The past few years brought a wealth of new data fostering our …