Strategies for durable β cell replacement in type 1 diabetes

TM Brusko, HA Russ, CL Stabler - Science, 2021 - science.org
Technological advancements in blood glucose monitoring and therapeutic insulin
administration have improved the quality of life for people with type 1 diabetes. However …

Advances in encapsulation and delivery strategies for islet transplantation

S Wu, L Wang, Y Fang, H Huang… - Advanced healthcare …, 2021 - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease caused by the destruction of
pancreatic β‐cells in response to autoimmune reactions. Shapiro et al. conducted novel islet …

[HTML][HTML] Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway

C Hu, Z Wu, Z Huang, X Hao, S Wang, J Deng, Y Yin… - Redox biology, 2021 - Elsevier
Aberrant placental angiogenesis is associated with fetal intrauterine growth restriction
(IUGR), but the mechanism underlying abnormal placental angiogenesis remains largely …

Towards a functional cure for diabetes using stem cell-derived beta cells: are we there yet?

S Bourgeois, T Sawatani, A Van Mulders, N De Leu… - Cells, 2021 - mdpi.com
Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

Structural basis for vascular endothelial growth factor receptor activation and implications for disease therapy

F Shaik, GA Cuthbert, S Homer-Vanniasinkam… - Biomolecules, 2020 - mdpi.com
Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety
of cells to regulate diverse biological responses. The VEGF-A family member promotes …

[HTML][HTML] Enhancing longevity of immunoisolated pancreatic islet grafts by modifying both the intracapsular and extracapsular environment

T Qin, AM Smink, P de Vos - Acta Biomaterialia, 2023 - Elsevier
Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease characterized by
autoimmune destruction of pancreatic β cells. Transplantation of immunoisolated pancreatic …

Gel formulated with Bryophyllum pinnatum leaf extract promotes skin wound healing in vivo by increasing VEGF expression: A novel potential active ingredient for …

ERD Araújo, JB Xavier-Santos, VC Da Silva… - Frontiers in …, 2023 - frontiersin.org
Bryophyllum pinnatum (Crassulaceae) is used in traditional medicine for treating skin
wounds. In our previous study, a topical gel containing B. pinnatum aqueous leaf extract …

[HTML][HTML] In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo

F Fantuzzi, S Toivonen, AA Schiavo, H Chae… - Frontiers in Cell and …, 2022 - frontiersin.org
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells
represents an important cell source for diabetes research. Here, we fully characterized iPSC …

Anti-angiogenic therapy in the treatment of non-small cell lung cancer

W Tian, C Cao, L Shu, F Wu - OncoTargets and therapy, 2020 - Taylor & Francis
Angiogenesis plays an essential role in the development of most solid tumors by delivering
nutrients and oxygen to the tumor. Therefore, anti-angiogenic therapy, particularly anti-VEGF …

[HTML][HTML] Shielding islets with human amniotic epithelial cells enhances islet engraftment and revascularization in a murine diabetes model

F Lebreton, K Bellofatto, CH Wassmer, L Perez… - American Journal of …, 2020 - Elsevier
Hypoxia is a major cause of considerable islet loss during the early posttransplant period.
Here, we investigate whether shielding islets with human amniotic epithelial cells (hAECs) …