Determining the interaction behavior of calf thymus DNA with anastrozole in the presence of histone H1: Spectroscopies and cell viability of MCF-7 cell line …

N Zare-Feizabadi, Z Amiri-Tehranizadeh… - DNA and Cell …, 2021 - liebertpub.com
The interaction of calf thymus DNA (ct DNA) with anastrozole, which is acknowledged as an
antineoplastic drug, has been enquired into in the absence and presence of histone H1 …

Multi-spectroscopic investigation, molecular docking and molecular dynamic simulation of competitive interactions between flavonoids (quercetin and rutin) and …

NA Alsaif, TA Wani, AH Bakheit, S Zargar - International Journal of …, 2020 - Elsevier
The main mechanism for drug-drug interaction is displacement reaction of ligands from their
protein binding sites. The aim of this study was to evaluate anticancer drug sorafenib …

Exploring the binding mechanism and adverse toxic effects of persistent organic pollutant (dicofol) to human serum albumin: A biophysical, biochemical and …

S Zargar, TA Wani - Chemico-Biological Interactions, 2021 - Elsevier
The organochlorine pesticide dicofol (DCF), a persistent organic pollutant, is used as
acaricide worldwide. Considering its large consumption in the agriculture sector and …

Mechanistic competitive binding interaction study between olmutinib and colchicine with model transport protein using spectroscopic and computer simulation …

TA Wani, AH Bakheit, S Zargar, S Alamery - Journal of Photochemistry and …, 2022 - Elsevier
Drug-drug interactions are due to the binding of a drug to plasma proteins displacing
another plasma protein-bound drug. Two ligands, olmutinib (OLM) and colchicine (COL) …

[HTML][HTML] Toxicity Study and Binding Analysis of Newly Synthesized Antifungal N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide Derivative …

TA Wani, AH Bakheit, S Zargar, N Altwaijry… - International Journal of …, 2023 - mdpi.com
The presence of the p-aryl/cyclohexyl ring in the N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl
carbonyl) hydrazine carbothioamide derivative (2C) is reported to enhance the antifungal …

[HTML][HTML] Influence of rutin, sinapic acid, and naringenin on binding of tyrosine kinase inhibitor erlotinib to bovine serum albumin using analytical techniques along with …

TA Wani, AH Bakheit, S Zargar, AIA Khayyat… - Applied Sciences, 2022 - mdpi.com
Flavonoid-containing food supplements are widely used as antioxidants, and the continuous
use of these supplements with other drugs can lead to clinically significant interactions …

Different commercial soy protein isolates and the characteristics of Chiba tofu

L Zheng, ZJ Wang, Y Kong, ZL Ma, CL Wu… - Food …, 2021 - Elsevier
Twenty different cold gels were made by adding transglutaminase enzyme and using soy
protein isolate (SPI) powders from different manufacturers to investigate their potential as an …

[HTML][HTML] Interaction characterization of a tyrosine kinase inhibitor erlotinib with a model transport protein in the presence of quercetin: A drug–protein and drug–drug …

TA Wani, MM Alanazi, NA Alsaif, AH Bakheit, S Zargar… - Molecules, 2022 - mdpi.com
The interaction between erlotinib (ERL) and bovine serum albumin (BSA) was studied in the
presence of quercetin (QUR), a flavonoid with antioxidant properties. Ligands bind to the …

Interaction of an abiraterone with calf thymus DNA: Investigation with spectroscopic technique and modelling studies

TA Wani, N Alsaif, AH Bakheit, S Zargar… - Bioorganic …, 2020 - Elsevier
Binding of toxic ligands to DNA could result in undesirable biological processes, such as
carcinogenesis or mutagenesis. Binding mode of Abiraterone (ABR), a steroid drug and calf …

Influence of antioxidant flavonoids quercetin and rutin on the in-vitro binding of neratinib to human serum albumin

TA Wani, AH Bakheit, S Zargar, ZS Alanazi… - … Acta Part A: Molecular …, 2021 - Elsevier
This study was designed to examine the interaction of neratinib (NRB) with human serum
albumin (HSA) in presence of flavonoids quercetin and rutin. Both quercetin and rutin can …