Abstract Monopolar spindle1 (Mps1, also known as TTK) is the core component of the
spindle assembly checkpoint, which functions to ensure proper distribution of chromosomes …

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers
worldwide and the fourth most lethal cancer in China. However, although genomic studies …

Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

The centrosome is the major microtubule-organizing center in animal cells but is
dispensable for proper microtubule spindle formation in many biological contexts and is thus …

Epstein-Barr virus (EBV) is etiologically linked to infectious mononucleosis and several
human cancers. EBV encodes a conserved protein kinase BGLF4 that plays a key role in the …

Breast cancers (BC) carry a complex set of gene mutations that can influence their gene
expression and clinical behavior. We aimed to identify genes driven by the TP53 mutation …

Melanoma is commonly driven by activating mutations in the MAP kinase BRAF; however,
oncogenic BRAF alone is insufficient to promote melanomagenesis. Instead, its expression …

Melanomas and other solid tumors commonly have increased ploidy, with near-tetraploid
karyotypes being most frequently observed. Such karyotypes have been shown to arise …

Background Esophageal squamous cell carcinoma (ESCC) is the sixth most lethal cancer
worldwide and the fourth most lethal cancer in China. Genomic characterization of tumors …

Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells
they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is …