Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

m6A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2‐mediated IGF1R mRNA stabilization

C Lang, C Yin, K Lin, Y Li, Q Yang, Z Wu… - Clinical and …, 2021 - Wiley Online Library
Background Bone metastasis is the leading cause of tumor‐related death in prostate cancer
(PCa) patients. Long noncoding RNAs (lncRNAs) have been well documented to be …

[HTML][HTML] Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression

F Nie, X Yu, M Huang, Y Wang, M Xie, H Ma, Z Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Recently, long noncoding RNAs have been emerged as critical regulators of human disease
and prognostic markers in several cancers, including gastric cancer. In this study, we …

Long non-coding RNAs in genitourinary malignancies: a whole new world

R Flippot, G Beinse, A Boilève, J Vibert… - Nature Reviews …, 2019 - nature.com
Long non-coding RNAs (lncRNAs) are regulators of cellular machinery that are commonly
dysregulated in genitourinary malignancies. Accordingly, the investigation of lncRNAs is …

Androgen receptor deregulation drives bromodomain-mediated chromatin alterations in prostate cancer

A Urbanucci, SJ Barfeld, V Kytölä, HM Itkonen… - Cell reports, 2017 - cell.com
Global changes in chromatin accessibility may drive cancer progression by reprogramming
transcription factor (TF) binding. In addition, histone acetylation readers such as …

Long non-coding RNAs in prostate cancer: Functional roles and clinical implications

YH Xu, JL Deng, G Wang, YS Zhu - Cancer letters, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) are defined as RNA transcripts longer than 200
nucleotides that do not encode proteins. LncRNAs have been documented to exhibit …

Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression

L Latonen, E Afyounian, A Jylhä, J Nättinen… - Nature …, 2018 - nature.com
To understand functional consequences of genetic and transcriptional aberrations in
prostate cancer, the proteomic changes during disease formation and progression need to …

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

JA Oo, K Pálfi, T Warwick, I Wittig, C Prieto-Garcia… - Cell reports, 2022 - cell.com
In healthy vessels, endothelial cells maintain a stable, differentiated, and growth-arrested
phenotype for years. Upon injury, a rapid phenotypic switch facilitates proliferation to restore …

Pro-tumorigenic role of lnc-ZNF30-3 as a sponge counteracting miR-145-5p in prostate cancer

M Le Hars, LJ Castro-Vega, F Rajabi, D Tabatadze… - Biology Direct, 2023 - Springer
Background Prostate cancer remains one of the deadliest neoplasms in developed
countries. Identification of new molecular markers that predict the onset and progression of …