In order to investigate the potential neuroprotective role played by glucose metabolism
during brain oxygen deprivation, the susceptibility of cultured neurones and astrocytes to 1 h …

Oxidative stress and Ca2+ toxicity are mechanisms of hypoxic–ischemic (HI) brain injury.
This work investigates if partial inhibition of mitochondrial respiratory chain protects HI brain …

Being the second most common cause of death in the industrial countries and one of the
major causes of death and disability, stroke has a great effect on public health and is the …

Background Mitochondrial dysfunction is one of the major events responsible for activation
of neuronal cell death pathways during cerebral ischemia. Trace element selenium has …

Necrosis and apoptosis have been initially identified as two exclusive pathways for cell
death. In acute brain lesions, such as focal ischemia, this binary scheme is challenged by …

Cerebral hypoxia/ischemia leads to mitochondrial dysfunction due to lack of oxygen leaving
the glycolytic metabolism as a main pathway for ATP production. Inhibition of mitochondrial …

In this article we demonstrate the immunocytochemical localization of nitric oxide synthase
in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal …

Ischemic stroke and neonatal hypoxic-ischemic encephalopathy are two of the leading
causes of disability in adults and infants. The energy demands of the brain are provided by …

Background and Purpose—Ischemic brain injury is characterized by 2 temporally distinct but
interrelated phases: ischemia (primary energy failure) and reperfusion (secondary energy …

Mitochondria represent both the main source and target of reactive oxygen and nitrogen
species (RONS). In view of the large energy expenditure made by neurons during …