Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

Background High expression of immune checkpoints in tumor microenvironment plays
significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis …

Plant stress is a significant challenge that affects the development, growth, and productivity
of plants and causes an adverse environmental condition that disrupts normal physiological …

Mammalian pregnancy involves tremendous de novo maternal vascular construction to
adequately support conceptus development. In early mouse decidua basalis (DB), maternal …

The advent of high throughput next generation sequencing (NGS) has accelerated the pace
of discovery of disease-associated genetic variants and genomewide profiling of expressed …

Adverse in utero events can alter the development and function of numerous physiological
systems, giving rise to lasting neurodevelopmental deficits. In particular, data have shown …

Background Per-and polyfluoroalkyl substances (PFAS) are chemicals that are resistant to
degradation and ubiquitous in our environments. PFAS may impact the developing …

DNA methylation is the most widely-studied epigenetic modification, playing a critical role in
the regulation of gene expression. Dysregulation of DNA methylation is implicated in the …