Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types.
PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition …

The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as
ornamental plants. These plants are also valued in traditional medicine. Among all Papaver …

Deregulated Rho GTPases Rac1 and Cdc42 have been discovered in various tumors,
including prostate and Rac protein expression significantly increases in prostate cancer. The …

Introduction: Despite the abundance of research indicating the participation of immune cells
in prostate cancer development, establishing a definitive cause-and-effect relationship has …

Background Epidermal growth factor receptor (EGFR) is upregulated in prostate cancer
(PCa). However, suppression of EGFR did not improve the patient outcome, possibly due to …

The androgen receptor (AR) stimulates and represses gene expression to promote the
initiation and progression of prostate cancer. Here, we report that androgen represses the …

CTLA-4 is a negative regulator of the proliferation and the effector function of T-cells.
Therefore, it might be important to determine its expression on tumor cells and T …

There is significant need to identify novel prostate cancer drug targets because current
hormone therapies eventually fail, leading to a drug-resistant and fatal disease termed …

Dihydroartemisinin (DHA) is a derivative of artemisinin and is an effective anti-malaria
therapeutic used worldwide. In this report, we report that DHA is as a potential anti-cancer …

The desmosomal cadherin, desmoglein 2 (Dsg2), is deregulated in a variety of human
cancers including those of the skin. When ectopically expressed in the epidermis of …