Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Mitochondrial production of superoxide and hydrogen peroxide is potentially important in
cell signaling and disease. Eleven distinct mitochondrial sites that differ markedly in capacity …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

The brain plays a key role in the controls of energy intake and expenditure, and many genes
associated with obesity are expressed in the central nervous system. Technological and …

The average lifespan of humans is increasing, and with it the percentage of people entering
the 65 and older age group is growing rapidly and will continue to do so in the next 20 years …

The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

Abstract Purpose of Review Obesity and obesity-related diseases, largely resulting from
urbanization and behavioral changes, are now of global importance. Energy restriction …

Most nations of the world are undergoing rapid and dramatic population ageing, which
presents great socio‐economic challenges, as well as opportunities, for individuals, families …

Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …