Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of …

P Maiti, Z Bowers, A Bourcier-Schultz, J Morse… - Alzheimer's research & …, 2021 - Springer
Background Synaptic failure is one of the principal events associated with cognitive
dysfunction in Alzheimer's disease (AD). Preservation of existing synapses and prevention …

GPNMB mitigates Alzheimer's disease and enhances autophagy via suppressing the mTOR signal

Z Zhu, Y Liu, X Li, L Zhang, H Liu, Y Cui, Y Wang… - Neuroscience …, 2022 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disease which is characterized
by amyloid beta (Aβ) accumulation. We found that glycoprotein NMB (GPNMB) was highly …

Zingiber officinale Roscoe: A comprehensive review of clinical properties

A Bitari, I Oualdi, R Touzani, M Elachouri… - Materials Today …, 2023 - Elsevier
Zingiber officinale Roscoe, commonly known as ginger, is widely used as a spice or a folk
medicine. Such a plant has been incuriously focused on by publishing extensive papers and …

The application of nanotechnology in treatment of Alzheimer's disease

Y Cao, R Zhang - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
The buildup of beta-amyloid plaques in the brain results in Alzheimer's disease (AD), a
neurodegenerative condition. A permanent treatment for AD is not yet available. Only a …

Neurological involvement of COVID-19: from neuroinvasion and neuroimmune crosstalk to long-term consequences

DE Septyaningtrias, R Susilowati - Reviews in the Neurosciences, 2021 - degruyter.com
As the coronavirus disease 2019 (COVID-19) pandemic continues to be a multidimensional
threat to humanity, more evidence of neurological involvement associated with it has …

[HTML][HTML] Direct pulmonary delivery of solubilized curcumin reduces severity of lethal pneumonia

B Zhang, S Swamy, S Balijepalli, S Panicker… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is
associated with reduced lung compliance and hypoxemia. Curcumin exhibits potent anti …

Alzheimer, Parkinson, dementia, and phytochemicals: Insight review

B Can, N Sanlier - Critical reviews in food science and nutrition, 2023 - Taylor & Francis
Abstract Alzheimer's, Parkinson's, and dementia are the leading neurodegenerative
diseases that threaten the world with the aging population. Although the pathophysiology of …

Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimer's disease

X Zhou, M Venigalla, R Raju, G Münch - Journal of Neural Transmission, 2022 - Springer
Abstract Prof. Dr. Peter Riederer, the former Head of the Neurochemistry Department of the
Psychiatry and Psychotherapy Clinic at the University of Würzburg (Germany), has been one …

Chemical perspective of the mechanism of action of antiamyloidogenic compounds using a minimalistic peptide as a reductionist model

B Koshti, V Kshtriya, C Nardin… - ACS Chemical …, 2021 - ACS Publications
The diphenylalanine (FF) residue which is present at the 19 and 20 positions of the amyloid
beta (1–42)(Aβ42) peptide sequence is considered as a reductionist model for studying …

Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351

JY Park, HY Sohn, YH Koh, C Jo - Scientific Reports, 2021 - nature.com
Curcumin, a phytochemical extracted from Curcuma longa rhizomes, is known to be
protective in neurons via activation of Nrf2, a master regulator of endogenous defense …