Adipose tissue–derived human mesenchymal stem cells mediated prodrug cancer gene therapy
L Kucerova, V Altanerova, M Matuskova, S Tyciakova… - Cancer research, 2007 - AACR
Human adipose tissue–derived mesenchymal stem cells (AT-MSC) are considered to be a
promising source of autologous stem cells in personalized cell-based therapies. Tumor …
promising source of autologous stem cells in personalized cell-based therapies. Tumor …
HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells
M Matuskova, K Hlubinova, A Pastorakova… - Cancer letters, 2010 - Elsevier
Previously we have reported adipose-tissue derived human mesenchymal stem cells (AT-
MSC) as cellular delivery vehicles for tumor-targeted cancer gene therapy. In this report we …
MSC) as cellular delivery vehicles for tumor-targeted cancer gene therapy. In this report we …
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
L Kucerova, M Matuskova… - The Journal of Gene …, 2008 - Wiley Online Library
Background Previously, we validated capability of human adipose tissue‐derived
mesenchymal stem cells (AT‐MSC) to serve as cellular vehicles for gene‐directed enzyme …
mesenchymal stem cells (AT‐MSC) to serve as cellular vehicles for gene‐directed enzyme …
[HTML][HTML] Extracellular vesicles derived from dental mesenchymal stem/stromal cells with gemcitabine as a cargo have an inhibitory effect on the growth of pancreatic …
D Klimova, J Jakubechova, U Altanerova… - Molecular and Cellular …, 2023 - Elsevier
Extracellular vesicles (EVs) are nowadays a target of interest in cancer therapy as a
successful drug delivering tool. Based on their many beneficial biocompatible properties are …
successful drug delivering tool. Based on their many beneficial biocompatible properties are …
Mesenchymal stromal cells retrovirally transduced with prodrug-converting genes are suitable vehicles for cancer gene therapy.
E Ďuriniková, L Kučerová, M Matúšková - Acta virologica, 2014 - europepmc.org
Mesenchymal stem/stromal cells (MSC) possess a set of several fairly unique properties
which make them ideally suitable both for cellular therapies and regenerative medicine …
which make them ideally suitable both for cellular therapies and regenerative medicine …
Genetically engineered mesenchymal stromal cells producing TNFα have tumour suppressing effect on human melanoma xenograft
S Tyciakova, M Matuskova, R Bohovic… - The Journal of Gene …, 2015 - Wiley Online Library
Background Mesenchymal stromal cells (MSC) are a promising tool for targeted cancer
therapy due to their tumour‐homing ability. Intrinsic resistance enables the MSC to longer …
therapy due to their tumour‐homing ability. Intrinsic resistance enables the MSC to longer …
[HTML][HTML] Increased proliferation and chemosensitivity of human mesenchymal stromal cells expressing fusion yeast cytosine deaminase
L Kucerova, M Poturnajova, S Tyciakova… - Stem cell research, 2012 - Elsevier
Mesenchymal stromal cells (MSCs) are considered to be suitable vehicles for cellular
therapy in various conditions. The expression of reporter and/or effector protein (s) enabled …
therapy in various conditions. The expression of reporter and/or effector protein (s) enabled …
Cytotoxic response of 5-fluorouracil-resistant cells to gene-and cell-directed enzyme/prodrug treatment
E Durinikova, J Plava, S Tyciakova, P Skvara… - Cancer Gene …, 2018 - nature.com
Gene-directed enzyme/prodrug therapy (GDEPT) mediated by mesenchymal stromal cells
(MSC) was already approved for clinical study on a progressive disease refractory to …
(MSC) was already approved for clinical study on a progressive disease refractory to …
[PDF][PDF] 阳离子脂质体介导HSV-TK/ACV 系统对人脑胶质瘤细胞增殖活性的影响
苏君, 杨海城, 肖宏, 张学新 - 肿瘤防治研究, 2002 - zlfzyj.com
摘要目的探讨HSV TK/ACV 系统对人脑胶质瘤细胞增殖活性的影响. 方法用阳离子脂质体
Lipofectamine 将pCR3 Uni 及含HSV TK 基因的真核表达载体pCR3 TK 转染至人脑胶质瘤细胞 …
Lipofectamine 将pCR3 Uni 及含HSV TK 基因的真核表达载体pCR3 TK 转染至人脑胶质瘤细胞 …
[PDF][PDF] Retrovirus vector containing wild type p53 gene and its effect on human glioma cells
J Hlavatý, S Tyukosova, J Bies, K Hlubinova… - Neoplasma, 2000 - researchgate.net
A retroviral vector containing wild-type p53 tumor suppressor gene (wt-p53) under the
control of viral LT R sequences was constructed and transfected into packaging cell line G?+ …
control of viral LT R sequences was constructed and transfected into packaging cell line G?+ …