14th International Congress on Antiphospholipid Antibodies Task Force report on obstetric antiphospholipid syndrome

GR de Jesus, N Agmon-Levin, CA Andrade… - Autoimmunity …, 2014 - Elsevier
Pregnancy morbidity is one of the clinical manifestations used for classification criteria of
antiphospholipid syndrome (APS). During the 14th International Congress on …

The implications of autoimmunity and pregnancy

AT Borchers, SM Naguwa, CL Keen… - Journal of autoimmunity, 2010 - Elsevier
There are multiple epidemiological studies that document the potential adverse affects of
autoimmunity on nearly every aspect of reproduction, even in the absence of clinically …

The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis

JH Rand, XX Wu, AS Quinn, DJ Taatjes - Lupus, 2010 - journals.sagepub.com
Annexin A5 (AnxA5) binds to phospholipid bilayers, forming two-dimensional crystals that
block the phospholipids from availability for coagulation enzyme reactions. Antiphospholipid …

Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases

L Iaccarino, A Ghirardello, M Canova, M Zen… - Autoimmunity …, 2011 - Elsevier
Annexins are a group of 12 highly conserved proteins which exert several regulatory
functions on cell biology. There are involved in numerous cell processes including vesicle …

Resistance to annexin A5 anticoagulant activity: a thrombogenic mechanism for the antiphospholipid syndrome

JH Rand, XX Wu, AS Quinn, DJ Taatjes - Lupus, 2008 - journals.sagepub.com
The phospholipid binding protein, annexin A5 (AnxA5), has potent anticoagulant properties
that result from its forming 2-dimensional crystals over phospholipids, blocking the …

Anti‐phospholipid antibodies and reproductive failures

A Beltagy, L Trespidi, M Gerosa… - American Journal of …, 2021 - Wiley Online Library
Anti‐phospholipid syndrome (APS) recapitulates the link between autoimmunity and
pregnancy failure: Acquired anti‐phospholipid antibodies (aPL) play a pathogenic role in …

Recurrent miscarriage and autoimmunity

AS Bansal, B Bajardeen, H Shehata… - Expert review of clinical …, 2011 - Taylor & Francis
Both organ-specific and systemic autoimmunity are associated with an increased
prevalence of recurrent miscarriage (RM). The precise mechanism for this is unclear, as …

Recurrent early pregnancy loss and antiphospholipid antibodies: where do we stand?

LF Wong, TF Porter, GR Jesús - Lupus, 2014 - journals.sagepub.com
Evidence from basic science studies supports a causative relationship between
antiphospholipid antibodies (aPL) and recurrent early miscarriage (REM)(prior to 10 weeks …

The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome

M Bećarević - Journal of thrombosis and thrombolysis, 2016 - Springer
Antiphospholipid syndrome (APS) is an autoimmune disease that is characterized by the
presence of thromboses and/or recurrent pregnancy losses (RPL). The persistent presence …

[HTML][HTML] “In House” assays for the quantification of Annexin V and its autoantibodies in patients with recurrent pregnancy loss and in vitro fertilisation failures

H Murad, B Ali, A Twair, K Baghdadi, M Alhalabi… - Scientific Reports, 2023 - nature.com
Several studies have been shown that Annexin V (ANXV) autoantibodies concentrations are
associated with both early recurrent pregnancy losses (RPLs) or in vitro fertilization failure …