AMPK as a therapeutic target for treating metabolic diseases
EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …
[HTML][HTML] Metformin: from mechanisms of action to therapies
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
Anti-inflammatory effects of metformin irrespective of diabetes status
AR Cameron, VL Morrison, D Levin, M Mohan… - Circulation …, 2016 - Am Heart Assoc
Rationale: The diabetes mellitus drug metformin is under investigation in cardiovascular
disease, but the molecular mechanisms underlying possible benefits are poorly understood …
disease, but the molecular mechanisms underlying possible benefits are poorly understood …
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids
SJ Mun, JS Ryu, MO Lee, YS Son, SJ Oh, HS Cho… - Journal of …, 2019 - Elsevier
Background & Aims The development of hepatic models capable of long-term expansion
with competent liver functionality is technically challenging in a personalized setting. Stem …
with competent liver functionality is technically challenging in a personalized setting. Stem …
[HTML][HTML] The therapeutic potential of metformin in neurodegenerative diseases
C Rotermund, G Machetanz… - Frontiers in endocrinology, 2018 - frontiersin.org
The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …
today's aging population and an increasing burden on individuals, families, and society …
Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice
Background & Aims Transmembrane protein 173 (TMEM173 or STING) signaling by
macrophage activates the type I interferon-mediated innate immune response. The innate …
macrophage activates the type I interferon-mediated innate immune response. The innate …
Metformin: an old drug with new applications
Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more
than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown …
than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown …
Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis
Monocyte-to-macrophage differentiation is a critical event that accentuates atherosclerosis
by promoting an inflammatory environment within the vessel wall. In this study, we …
by promoting an inflammatory environment within the vessel wall. In this study, we …
Metformin, macrophage dysfunction and atherosclerosis
Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …
treat many diseases. More and more evidence shows that metformin can regulate the …
Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators
E Piccinin, G Villani, A Moschetta - Nature reviews Gastroenterology & …, 2019 - nature.com
Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …