Role of Nrf2, STAT3, and Src as molecular targets for cancer chemoprevention

H Ahsan, SU Islam, MB Ahmed, YS Lee - Pharmaceutics, 2022 - mdpi.com
Cancer is a complex and multistage disease that affects various intracellular pathways,
leading to rapid cell proliferation, angiogenesis, cell motility, and migration, supported by …

The dual and multifaceted role of relaxin-2 in cancer

LB Kwantwi - Clinical and Translational Oncology, 2023 - Springer
The continuous increase in cancer-associated deaths despite the substantial improvement
in diagnosis and treatment has sparked discussions on the need for novel biomarkers and …

CRISPRi screens identify the lncRNA, LOUP, as a multifunctional locus regulating macrophage differentiation and inflammatory signaling

H Halasz, E Malekos, S Covarrubias… - Proceedings of the …, 2024 - National Acad Sciences
Long noncoding RNAs (lncRNAs) account for the largest portion of RNA from the
transcriptome, yet most of their functions remain unknown. Here, we performed two …

[HTML][HTML] A signature constructed with mitophagy-related genes to predict the prognosis and therapy response for breast cancer

Y Zhao, Y Zhang, C Dai, K Hong, Y Guo - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Over the past decades, the incidence and mortality rates of breast cancer (BC) have
increased rapidly; however, molecular biomarkers that can reliably detect BC are yet to be …

Potential chemopreventive role of pterostilbene in its modulation of the apoptosis pathway

O Surien, SF Masre, DF Basri, AR Ghazali - International Journal of …, 2023 - mdpi.com
Cancer incidence keeps increasing every year around the world and is one of the leading
causes of death worldwide. Cancer has imposed a major burden on the human population …

Fucoidan's molecular targets: A comprehensive review of its unique and multiple targets accounting for promising bioactivities supported by in silico studies

A Zayed, DA Al-Saedi, EO Mensah, ON Kanwugu… - Marine Drugs, 2023 - mdpi.com
Fucoidan is a class of multifunctional polysaccharides derived from marine organisms. Its
unique and diversified physicochemical and chemical properties have qualified them for …

Transcriptomics-based investigation of molecular mechanisms underlying apoptosis induced by ZnO nanoparticles in human diffuse large B-cell lymphoma

SA Alsagaby - International Journal of Nanomedicine, 2022 - Taylor & Francis
Introduction Zinc oxide nanoparticles (ZnO NPs) show anti-cancer activity. Diffuse Large B-
cell Lymphoma (DLBCL) is a type of B-cell malignancies with unsatisfying treatment …

Curcumin potentiates the anti-inflammatory effects of Tehranolide by modulating the STAT3/NF-κB signaling pathway in breast and ovarian cancer cell lines

H Afshari, S Noori, A Zarghi - Inflammopharmacology, 2023 - Springer
Background Studies have demonstrated that natural products, such as curcumin and
artemisinin, possess anti-inflammatory effects, which can be beneficial for cancer treatment …

Polyethyleneglycol-betulinic acid (PEG-BA) polymer-drug conjugate induces apoptosis and antioxidation in a biological model of pancreatic cancer

KS Mosiane, EE Nweke, M Balogun, PN Fru - Polymers, 2023 - mdpi.com
Pancreatic cancer (PC) is one of the most aggressive solid malignancies with poor treatment
response and low survival rates. Herbal medicines such as betulinic acid (BA) have shown …

Macrophage activation by exopolysaccharides from Streptococcus thermophilus fermented milk through TLRs-mediated NF-κB and MAPK pathways

W Xu, F Cao, M Zhao, X Fu, S Yin, Y Sun… - International …, 2022 - Elsevier
Lactic acid bacteria-derived exopolysaccharides are known for stimulating immune
responses. In our previous study, a novel exopolysaccharide (EPS-3A) from skimmed milk …