Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz.(Baill.), a current review

Y Zhou, L Men, Y Sun, M Wei, X Fan - European Journal of Pharmacology, 2021 - Elsevier
Abstract Fruit of Schisandra chinensis Turcz.(Baill.)(S. chinensis) is a traditional herbal
medicine widely used in China, Korea, and many other east Asian countries. At present, S …

A review of traditional Chinese medicine on treatment of diabetic nephropathy and the involved mechanisms

XJ Liu, XK Hu, H Yang, LM Gui, ZX Cai… - The American journal …, 2022 - World Scientific
Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus
(DM), which can lead to renal failure in diabetic patients. At present, the first-line drugs for …

Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway

LS Yan, SF Zhang, G Luo, BCY Cheng, C Zhang… - Metabolism, 2022 - Elsevier
Abstract Background Schisandrin B (Sch B), which inhibits hepatic steatosis caused by non-
alcoholic fatty liver disease (NAFLD), is one of the most active dibenzocyclooctadienes …

Schisandrin B attenuates airway inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis

X Chen, Z Xiao, Z Jiang, Y Jiang, W Li, M Wang - Inflammation, 2021 - Springer
Asthma is a chronic inflammatory disorder of the airways. Schisandrin B (SB) is the main
effective component. This study investigated the effects of SB on airway inflammation and …

Schisandrin B attenuates diabetic cardiomyopathy by targeting MyD88 and inhibiting MyD88‐dependent inflammation

W Luo, K Lin, J Hua, J Han, Q Zhang, L Chen… - Advanced …, 2022 - Wiley Online Library
Diabetes manifests as chronic inflammation and leads to the development diabetic
cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new …

[HTML][HTML] Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy

D Liu, L Chen, H Zhao, ND Vaziri, SC Ma… - Biomedicine & …, 2019 - Elsevier
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

Lignans as pharmacological agents in disorders related to oxidative stress and inflammation: chemical synthesis approaches and biological activities

DI Osmakov, AP Kalinovskii, OA Belozerova… - International journal of …, 2022 - mdpi.com
Plant lignans exhibit a wide range of biological activities, which makes them the research
objects of potential use as therapeutic agents. They provide diverse naturally-occurring …

Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin‐Induced Hepatotoxicity

H Shi, Y Yan, H Yang, P Pu… - BioMed Research …, 2022 - Wiley Online Library
Objective. Pirarubicin (THP) is one of anthracycline anticancer drugs. It is widely used in the
treatment of various cancers, but its hepatotoxicity cannot be ignored. Schisandrin B (SchB) …

Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of Schisandra Chinensis Mixture on diabetic …

Y Ma, Y Deng, N Li, A Dong, H Li, S Chen… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Diabetic nephropathy (DN) is one of the most common
and serious microvascular complications of Diabetes mellitus (DM). The inflammatory …

Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice

T Wang, X Wen, Z Zhang, M Xie… - Human & Experimental …, 2021 - journals.sagepub.com
Diabetic nephropathy is a progressive kidney disease resulting from long-term
hyperglycaemia in diabetic patients, and the underlying mechanism is complex and lacks …