Homeostatic regulation of the intestinal enteroendocrine lineage hierarchy is a poorly
understood process. We resolved transcriptional changes during enteroendocrine …

Sex hormones exert a profound influence on gendered behaviors. How individual sex
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …

Adaptive behaviour crucially depends on flexible decision-making, which in mammals relies
on the frontal cortex, specifically the orbitofrontal cortex (OFC),,,,,,,–. How OFC encodes …

The cholinergic system in the brain plays crucial roles in regulating sensory and motor
functions as well as cognitive behaviors by modulating neuronal activity. Understanding the …

Enteroendocrine cells (EECs) control a wide range of physiological processes linked to
metabolism. We show that EEC hormones are differentially expressed between crypts (for …

To produce consistent sensory perception, neurons must maintain stable representations of
sensory input. However, neurons in many regions exhibit progressive drift across days …

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-
promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited …

Background The complement cascade not only provides protection from infection but can
also mediate destructive inflammation. Complement is also involved in elimination of …

Optogenetics allows manipulations of genetically and spatially defined neuronal populations
with excellent temporal control. However, neurons are coupled with other neurons over …

Neurons transmit information to distant brain regions via long-range axonal projections. In
the mouse, area-to-area connections have only been systematically mapped using bulk …