[HTML][HTML] Regional, layer, and cell-type-specific connectivity of the mouse default mode network
The evolutionarily conserved default mode network (DMN) is a distributed set of brain
regions coactivated during resting states that is vulnerable to brain disorders. How disease …
regions coactivated during resting states that is vulnerable to brain disorders. How disease …
[HTML][HTML] A photoswitchable GPCR-based opsin for presynaptic inhibition
Optical manipulations of genetically defined cell types have generated significant insights
into the dynamics of neural circuits. While optogenetic activation has been relatively …
into the dynamics of neural circuits. While optogenetic activation has been relatively …
[HTML][HTML] FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake
Summary Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the
liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in …
liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in …
[HTML][HTML] Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors
L Luo, MC Ambrozkiewicz, F Benseler, C Chen… - Neuron, 2020 - cell.com
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying …
knockin, and reporter expression in the mouse nervous system. However, we report varying …
[HTML][HTML] Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination
CL Call, DE Bergles - Nature communications, 2021 - nature.com
Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes
establish this pattern by selecting a cohort of axons for myelination; however, the distribution …
establish this pattern by selecting a cohort of axons for myelination; however, the distribution …
[HTML][HTML] Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making
Understanding how cortical circuits generate complex behavior requires investigating the
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …
A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …
[HTML][HTML] Circadian VIPergic neurons of the suprachiasmatic nuclei sculpt the sleep-wake cycle
Although the mammalian rest-activity cycle is controlled by a" master clock" in the
suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of individual …
suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of individual …
Specialized subpopulations of deep-layer pyramidal neurons in the neocortex: bridging cellular properties to functional consequences
Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …
[HTML][HTML] Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior
Respiration and airflow through the nasal cavity are known to be correlated with rhythmic
neural activity in the central nervous system. Here we show in rodents that during …
neural activity in the central nervous system. Here we show in rodents that during …