The mammalian hippocampal formation (HF) plays a key role in several higher brain
functions, such as spatial coding, learning and memory. Its simple circuit architecture is often …

Clostridioides difficile infection (CDI) is a major cause of healthcare-associated
gastrointestinal infections,. The exaggerated colonic inflammation caused by C. difficile …

Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the
ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein …

Daily and annual changes in light are processed by central clock circuits that control the
timing of behavior and physiology. The suprachiasmatic nucleus (SCN) in the anterior …

Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in
motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established …

Animals can store information about experiences by activating specific neuronal
populations, and subsequent reactivation of these neural ensembles can lead to recall of …

Synaptic inhibition critically influences sensory processing throughout the mammalian brain,
including the main olfactory bulb (MOB), the first station of sensory processing in the …

Identification of structural connections between neurons is a prerequisite to understanding
brain function. Here we developed a pipeline to systematically map brain-wide …

Full-length SMART-seq single-cell RNA sequencing can be used to measure gene
expression at isoform resolution, making possible the identification of specific isoform …

Animals depend on sensory feedback from mechanosensory afferents for the dynamic
control of movement. This sensory feedback needs to be selectively modulated in a task-and …