Artificial intelligence challenges for predicting the impact of mutations on protein stability
Stability is a key ingredient of protein fitness, and its modification through targeted mutations
has applications in various fields, such as protein engineering, drug design, and deleterious …
has applications in various fields, such as protein engineering, drug design, and deleterious …
[HTML][HTML] Analysis and interpretation of the impact of missense variants in cancer
Large scale genome sequencing allowed the identification of a massive number of genetic
variations, whose impact on human health is still unknown. In this review we analyze, by an …
variations, whose impact on human health is still unknown. In this review we analyze, by an …
Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset
Predicting the difference in thermodynamic stability between protein variants is crucial for
protein design and understanding the genotype-phenotype relationships. So far, several …
protein design and understanding the genotype-phenotype relationships. So far, several …
[HTML][HTML] SAAFEC-SEQ: a sequence-based method for predicting the effect of single point mutations on protein thermodynamic stability
Modeling the effect of mutations on protein thermodynamics stability is useful for protein
engineering and understanding molecular mechanisms of disease-causing variants. Here …
engineering and understanding molecular mechanisms of disease-causing variants. Here …
Protein engineering via Bayesian optimization-guided evolutionary algorithm and robotic experiments
Directed protein evolution applies repeated rounds of genetic mutagenesis and phenotypic
screening and is often limited by experimental throughput. Through in silico prioritization of …
screening and is often limited by experimental throughput. Through in silico prioritization of …
Mutant p53 activates hnRNPA2B1-AGAP1-mediated exosome formation to promote esophageal squamous cell carcinoma progression
R Feng, Y Yin, Y Wei, Y Li, L Li, R Zhu, X Yu, Y Liu… - Cancer Letters, 2023 - Elsevier
Abstract p53 mutations predispose cancer cell development, promote their survival and
metastasis, and lead to ineffective therapeutic responses and unfavorable prognosis. No …
metastasis, and lead to ineffective therapeutic responses and unfavorable prognosis. No …
Tools for computational design and high-throughput screening of therapeutic enzymes
Therapeutic enzymes are valuable biopharmaceuticals in various biomedical applications.
They have been successfully applied for fibrinolysis, cancer treatment, enzyme replacement …
They have been successfully applied for fibrinolysis, cancer treatment, enzyme replacement …
Web-based tools for computational enzyme design
Highlights•Enzymes are increasingly used in technological applications but often require
prior optimization.•Computational tools save time and effort in protein engineering …
prior optimization.•Computational tools save time and effort in protein engineering …
Unbiased curriculum learning enhanced global-local graph neural network for protein thermodynamic stability prediction
Motivation Proteins play crucial roles in biological processes, with their functions being
closely tied to thermodynamic stability. However, measuring stability changes upon point …
closely tied to thermodynamic stability. However, measuring stability changes upon point …
[HTML][HTML] Performance of Web tools for predicting changes in protein stability caused by mutations
Background Despite decades on developing dedicated Web tools, it is still difficult to predict
correctly the changes of the thermodynamic stability of proteins caused by mutations. Here …
correctly the changes of the thermodynamic stability of proteins caused by mutations. Here …