[HTML][HTML] Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

[HTML][HTML] Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine

C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

[HTML][HTML] Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial

SG Kelsen, IO Agache, W Soong, E Israel… - Journal of allergy and …, 2021 - Elsevier
Background The IL-33/ST2 pathway is linked with asthma susceptibility. Inhaled allergens,
pollutants, and respiratory viruses, which trigger asthma exacerbations, induce release of IL …

[HTML][HTML] Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review

A Strzelak, A Ratajczak, A Adamiec… - International journal of …, 2018 - mdpi.com
Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

Interleukin‐33 (IL‐33): a nuclear cytokine from the IL‐1 family

C Cayrol, JP Girard - Immunological reviews, 2018 - Wiley Online Library
Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

[HTML][HTML] Epithelial cell–derived cytokines: more than just signaling the alarm

F Roan, K Obata-Ninomiya… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Interleukin-33 in health and disease

FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

[HTML][HTML] Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?

F Qiu, CL Liang, H Liu, YQ Zeng, S Hou, S Huang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cigarette smoking is associated with numerous diseases and poses a serious challenge to
the current healthcare system worldwide. Smoking impacts both innate and adaptive …

[HTML][HTML] Environmental exposures and mechanisms in allergy and asthma development

LB Murrison, EB Brandt, JB Myers… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Environmental exposures interplay with human host factors to promote the development and
progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a …

Innate lymphoid cells: major players in inflammatory diseases

M Ebbo, A Crinier, F Vély, E Vivier - Nature Reviews Immunology, 2017 - nature.com
Recent years have seen a marked increase in our understanding of innate lymphoid cells
(ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets …