The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and
translation in the cytoplasm imposes the requirement of transporting thousands of …

Transport of macromolecules between the nucleus and cytoplasm is a critical cellular
process for eukaryotes, and the machinery that mediates nucleocytoplasmic exchange is …

Nuclear pore complexes (NPCs) gate the only conduits for nucleocytoplasmic transport in
eukaryotes. Their gate is formed by nucleoporins containing large intrinsically disordered …

Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. To analyze
their structure in a close-to-life state, we studied transport-active, intact nuclei from …

Eukaryotic cells are equipped with a machinery charged with the responsibility of
transporting a vast number of molecules in and out of the nucleus in a rapid, accurate, and …