Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Therapeutic approaches to metabolic syndrome (MetS) are numerous and may target
lipoproteins, blood pressure or anthropometric indices. Peroxisome proliferator-activated …

Blood lipid levels are heritable, treatable risk factors for cardiovascular disease. We
systematically assessed genome-wide coding variation to identify new genes influencing …

Macrophages, a key component of the innate defense against pathogens, participate in the
initiation and resolution of inflammation, and in the maintenance of tissues. These diverse …

Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone
receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma …

The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Cerebral vascular endothelial cell (CEC) degeneration significantly contributes to blood–
brain barrier (BBB) breakdown and neuronal loss after cerebral ischemia. Recently …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …