Lipid metabolism as a target for cancer drug resistance: progress and prospects

Z Wang, Y Wang, Z Li, W Xue, S Hu… - Frontiers in …, 2023 - frontiersin.org
Cancer is the world's leading cause of human death today, and the treatment process of
cancer is highly complex. Chemotherapy and targeted therapy are commonly used in cancer …

Exploring the potential role of genus Sophora in the management of osteoporosis: a phytochemical and biological review

SH Aly, AMM Elbadry, M El-Shazly… - Frontiers in Natural …, 2023 - frontiersin.org
Bone metabolism is characterized by an interplay between the deposition of bone matrix
and mineralization and the resorption process. Osteoporosis is a form of systemic metabolic …

Sophoridine Counteracts Obesity via Src-Mediated Inhibition of VEGFR Expression and PI3K/AKT Phosphorylation

J Sun, X Wang, Y He, X Tian, T Yuan, G Yang… - International Journal of …, 2024 - mdpi.com
Sophoridine (SRP) is a natural quinolizidine alkaloid found in many traditional Chinese
herbs, though its effect on adipose tissue is unclear. We improved serum lipid levels by …

Molecular mechanism of sophoridine in the treatment of prostate cancer based on cell experiments in vitro and network pharmacology

W Le, LU Chun-bin - NATURAL PRODUCT RESEARCH AND …, 2024 - trcw.ac.cn
The effect of Sophoridine (SRI) on the proliferation and apoptosis of DU-145 prostate cancer
cells, as well as its mechanism of action were investigated based on cell experiments in …

基于体外细胞实验和网络药理学探讨槐定碱治疗前列腺癌的作用机制

王乐, 芦春斌 - 天然产物研究与开发, 2024 - trcw.ac.cn
基于体外细胞实验, 网络药理学和分子对接探讨槐定碱(sophoridine, SRI) 对DU-145
前列腺癌细胞增殖, 凋亡的影响及其作用机制. MTT, 克隆形成以及免疫荧光实验检测SRI 对DU …