Cancer therapies based on T cells have shown impressive clinical benefit. In particular,
immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing …

Highlights•Successful immunotherapies must target a precise phenotype and strength of an
immune response.•Supramolecular materials may offer strategies for identifying and eliciting …

Supramolecular peptide assemblies with specific motifs have the advantages of high
immunogenicity, regulated immune response, and increased multiple functions in improving …

Vaccination has been one of the most successful breakthroughs in medical history. In recent
years, epitope-based subunit vaccines have been introduced as a safer alternative to …

Peptides are versatile building blocks for the fabrication of various nanostructures that result
in the formation of hydrogels and nanoparticles. Precise chemical functionalization promotes …

Currently approved replication-competent and inactivated vaccines are limited by excessive
reactogenicity and poor safety profiles, while subunit vaccines are often insufficiently …

Influenza vaccines that can be administered intranasally or by other needle-free delivery
routes have potential advantages over injected formulations in terms of patient compliance …

The central dogma of the action of current anticancer drugs is that the drug tightly binds to its
molecular target for inhibition. The reliance on tight ligand–receptor binding, however, is …

A supramolecular peptide vaccine system was designed in which epitope-bearing peptides
self-assemble into elongated nanofibers composed almost entirely of α-helical structure. The …

Surface modification of biomaterial can improve its biocompatibility and add new
biofunctions, such as targeting specific tissues, communication with cells, and modulation of …