Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most
frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis …

Background Identification of robust biomarkers of malignancy and methods to establish
disease progression is a major goal in paediatric neuro-oncology. We investigated whether …

Tumorigenesis is in many respects a process of dysregulated cellular evolution that drives
malignant cells to acquire six phenotypic hallmarks of cancer, including their ability to …

Telomerase expression is repressed in most somatic cells but is observed in stem cells and
a high percentage of human cancers and has been hypothesized to contribute to …

Telomere length in humans is emerging as a biomarker of aging because its shortening is
associated with aging-related diseases and early mortality. However, genetic mechanisms …

Alterations of several microRNA (miRNA) have been linked to cancer development and its
biology. To search for unique miRNA that might play a role in the development of anaplastic …

The ideal cancer treatment would specifically target cancer cells yet have minimal or no
adverse effects on normal somatic cells. Telomerase, the ribonucleoprotein reverse …

Telomerase is a ribonucleoprotein enzyme complex that adds telomeric repeats to the ends
of chromosomes. The core telomerase components are the telomerase reverse transcriptase …